Hyperemesis gravidarum - excessive vomiting in pregnancy Pregnancy and Childbirth Mild hyperemesis gravidarum
Conditions
Interventions
Intervention: Participants will receive either 4mg ondansetron every 8 hours or 10mg metoclopramide every 8 hours for 24 hours intravenously. Participants will also receive standard intravenous rehydr
Sponsors
University of Malaya (Malaysia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. First hospitalization for hyperemesis gravidarum (severe nausea and vomiting of pregnancy) 2. Gestation 16 weeks or less 3. Clinical dehydration with ketonuria on dipstick 4. Women in their first hospitalisation for presumed hyperemesis gravidarum
Exclusion criteria
Exclusion criteria: 1. Multiple gestation 2. Established non viable pregnancy 3. Pre-existing medical condition which can cause nausea and vomiting if known, for example: 3.1. Concomitant confounders of severity of nausea and vomiting e.g. culture proven symptomatic urinary tract infection, dengue fever 3.2. Gastrointestinal causes of vomiting e.g. gastro-enteritis 3.3. Medical causes of vomiting e.g. diabetic ketoacidosis 3.4. Allergy to metoclopramide or ondansetron
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Visual numerical rating scale score of overall wellbeing at 24 hours 2. Frequency of vomiting in the first 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Visual numerical rating scale score for nausea at enrolment, 8,16 and 24 hours 2. Adverse symptom profile 3. Ketonuria status at the end of 24 hour period 4. Treatment curtailment and changes 5. Total antiemetic drug dose 6. Length of hospital stay | — |
Countries
Malaysia
Outcome results
None listed