Uncomplicated lower urinary tract infection Urological and Genital Diseases Urinary tract infection
Conditions
Interventions
There are two intervention arms:
1. Ciprofloxacin 2 x 250 mg for three days (and one placebo per day)
2. Ibuprofen 3 x 400 mg for three days
Sponsors
Georg-August University of Gottingen (Georg-August-Universitat Gottingen, Universitatsmedizin) (Germany)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women with typical symptoms of uncomplicated lower urinary tract infection (dysuria, frequency, lower abdominal pain)
Exclusion criteria
Exclusion criteria: 1. Fever, low back pain 2. Urinary tract infection during the last two weeks 3. Current treatmant with antibiotics/Non-Steroidal Anti-Rheumatics (NSAR) 4. Pregnant/breastfeeding women 5. Diabetes 6. Renal diseases 7. Allergy/intolerance to ibuprofen/ciprofloxacin 8. Contraindications for trial medication 9. Severe co-morbidities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Symptom score on day 4 (symptom score for dysuria, frequency and pain is measured on days 0, 4 and 7 by questionnaire and interviews) 2. Feasibility: descriptive measure, this will be determined by describing the results of: 2.1. Recruitment of General Practitioners (GPs) 2.2. Recruitment of patients 2.3. Number of complete/incomplete data sets The feasibility will be assessed after the patient recruitment is finished. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improvement of symptoms at days 4 and 7 2. Adverse events 3. Number of relapses The trial duration for each patient is 28 days. The adverse effects and relapses within these 28 days will be concerned. We plan to find out about this by an interview on day 28, and by data collection from GPs data at monitoring visits. | — |
Countries
Germany
Outcome results
None listed