Pre-eclampsia Intrauterine growth restriction Pregnancy and Childbirth Pre-eclampsia
Conditions
Interventions
Vitamin C (1000 mg) and Vitamin E (400 IU) daily compared with placebo
Sponsors
The University of Adelaide (Australia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: All nulliparous women presenting to the antenatal clinic at the collaborating centre with a singleton pregnancy, between 14-22 weeks gestation, a normal blood pressure, and expected to give birth at the collaborating centre. Informed, written consent is necessary and there must be no contraindication to vitamin C or E therapy.
Exclusion criteria
Exclusion criteria: Women with any of the following: multiple pregnancy, life threatening fetal anomaly on ultrasound, known thrombophilia, chronic renal failure, hemochromatosis, women on heparin, warfarin or antihypertensive therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Incidence of small for gestational age infants 2. Clinical pre-eclampsia 3. Death or serious adverse pregnancy outcome for the infant | — |
Secondary
| Measure | Time frame |
|---|---|
| Severe adverse outcomes for the woman up to six weeks postpartum. | — |
Countries
Australia
Outcome results
None listed