DSM-IV cannabis use disorder Mental and Behavioural Disorders Mental and behavioural disorders due to psychoactive substance use
Conditions
Interventions
Treatment in the control condition consists of five to six months outpatient CBT, focused on enhancing the patient's motivation to change his addictive behaviour and subsequently changing his maladapt
Sponsors
The Netherlands Ministry of Health, Welfare and Sport (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. A history of cannabis abuse or cannabis dependency based on Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) in at least the year preceding the baseline assessment 2. Recent, regular use of cannabis, as indicated by self-reported cannabis consumption: 2.1. On two or more days a week during the three months preceding the start of the study 2.2. On two or more days a week during the three months preceding the entry of a controlled environment, provided that the controlled environment directly preceded the start of the study and started not longer ago than 90 days before the start of the study 3. Age ranging from 13 to 18 years 4. At least one (step) parent or legal guardian able and willing to participate in the treatment and in the required study assessments 5. Written informed consent, by both the adolescent and his or her parent or legal guardian
Exclusion criteria
Exclusion criteria: 1. Mental retardation, acute psychosis or acute suicidality 2. Inpatient or opioid substitution treatment is required, according to clinical judgement 3. Living outside the catchment area of the treatment centre 4. Inability to understand the Dutch language 5. Participation in another trial aimed at reduction of psycho-active substance use or delinquent behaviour
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study assessments take place at baseline and at three, six, nine and 12 months (end-point) following baseline. 1. Frequency of cannabis use (i.e. number of cannabis using days and number of joints smoked) in the 90 days preceding the month 12 assessment, based on the timeline follow back (TLFB) calender method. The study data are analysed using an intent-to-treat approach, in which all patients are included that were notified about their group allocation after randomisation. Efficacy of MDFT vs CBT in terms of the primary outcome measure is analysed by means of a 2 (treatment group: MDFT vs CBT) x 2 (time: baseline vs month 12) repeated measures MANOVA, using the baseline and month 12 datasets. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The percentage of treatment responders at month 12-treatment responders are defined as participants who have at least 30% less cannabis using days in the 90 days preceding the month 12 assesment compared to baseline, provided that this reduction is not at the expense of a substantial increase (more than 6 days in the past month) in the use of other substances (i.e. alcohol (at least five glasses a day), cocaine, amphetamines and ecstasy). Adolescents are considered to be in recovery if they live in the community (as opposed to being incarcerated or in inpatient treatment) and are completely abstinent from cannabis, alcohol (at least five glasses a day) and any other substance use on each of the 90 days preceding the month 12 assessment. 2. The percentage of recovered adolescents at month 12 3. The number of property and violent crimes committed in the 90 days preceding the month 12 assessment 4. Treatment retention-Treatment retention is defined as the number of weeks that a treatment session was attended by the adolescent. In addition, we calculate the total time of therapeutic contacts spent with the adolescent, parents and other family member or relevant extra-familial parties as an indicator of the total treatment dosage received. Adolescents are considered as treatment completers if they attended a treatment session in at least 75% of the planned number of treatment weeks. Based on a planned treatment duration of at least five months (22 weeks), this amounts to a minimum of 17 treatment weeks for both conditions. The difference in percentage of treatment responders between the study groups at month 12 is analysed in a logistic regression model, with treatment group as independent variable and treatment response as outcome variable. The same approach is used for analysing the difference in percentage of recovered adolescents at month 12. Differences in delinquent behaviour (property and violent | — |
Countries
Netherlands
Outcome results
None listed