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The Effectiveness of the Unified Protocol (UP) in Patients with Emotional Disorders

The Effectiveness of the Unified Protocol (UP) Compared to Treatment as Usual (TaU) on Neuroticism and Related Constructs in Patients with Emotional Disorders

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20260523069500N1
Enrollment
60
Registered
2026-05-28
Start date
2026-09-23
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emotional disorders (depressive and anxiety disorders).

Interventions

Intervention 1: Intervention group: The intervention group will receive the Unified Protocol (UP) transdiagnostic treatment protocol based on Barlow et al.’s therapist guide (2018) in the form of 12 w
Sessions 3–4: Increasing emotional awareness, self-monitoring training, and identifying emotional patterns
Sessions 5–6: Flexible cognitive appraisal, cognitive restructuring, and challenging negative thoughts
Sessions 7–9: Mindful emotional exposure and prevention of emotion-based avoidance behaviors
Sessions 10–11: Tolerance of physical discomfort, increasing behavioral activation, and strengthening adaptive behaviors
Session 12: Reviewing skills, relapse prevention, and planning for continued skills practice. Intervention 2: Control group: In treatment-as-usual Group (Psychoeducation), participants will have acces

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Diagnosis of at least one emotional disorder (including depressive disorders and anxiety spectrum disorders based on SCID-I). Age range between 18 and 55 years old. Ability to read and write. Willingness to participate in the research based on the terms of the written informed consent.

Exclusion criteria

Exclusion criteria: Use of psychiatric medication, or having a stable dosage of medication for at least 3 months prior to enrollment. Diagnosis of bipolar spectrum disorders, psychotic spectrum disorders, or schizotypal personality disorder (based on SCID-II). History of substance or alcohol abuse in the last 3 months. Receipt of Unified Protocol (UP) and/or CBT for emotional disorders in the last year, for more than 4 sessions.

Design outcomes

Primary

MeasureTime frame
Severity of depressive symptoms. Timepoint: Measurement of the severity of depressive symptoms at the beginning of the study (before the intervention), after the completion of the intervention, and 3 months after the completion of the intervention. Method of measurement: Depression Anxiety Stress Scales (DASS-21).;Severity of anxiety symptoms. Timepoint: Measurement of the severity of anxiety symptoms at the beginning of the study (before the intervention), after the completion of the intervention, and 3 months after the completion of the intervention. Method of measurement: Depression Anxiety Stress Scales (DASS-21).

Secondary

MeasureTime frame
Attentional Control. Timepoint: Measurement of the attentional control score at the beginning of the study (before the intervention), after the completion of the intervention, and 3 months after the completion of the intervention. Method of measurement: Attentional Control Scale (ACS).;Interoceptive Awareness. Timepoint: Measurement of the interoceptive awareness score at the beginning of the study (before the intervention), after the completion of the intervention, and 3 months after the completion of the intervention. Method of measurement: Multidimensional Assessment of Interoceptive Awareness (MAIA).;Emotional Self-Efficacy. Timepoint: Measurement of the emotional self-efficacy score at the beginning of the study (before the intervention), after the completion of the intervention, and 3 months after the completion of the intervention. Method of measurement: Emotional Self-Efficacy Scale (ESES).;Neuroticism. Timepoint: Measurement of the neuroticism score at the beginning of the study (before the intervention), after the completion of the intervention, and 3 months after the completion of the intervention. Method of measurement: NEO Five Factor Inventory-Neuroticism subscale (NEO-FFI-N).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Banafshe Mohajerin

Shahid Beheshti University of Medical Sciences

bmohajerin@sbmu.ac.ir+98 21 2243 9872

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026