comparing the effect of short acting benzodiazpine with long acting in chemical restraint of patients with acute agitation and violence distubance behavior, referred to arak valiasre hospital.
Conditions
Interventions
Intervention 1: Intervention group: Intervention group: Group 1: Midazolam (short-acting benzodiazepine) Drug: Midazolam (5 mg ampoule) Dosage and administration: Slow intravenous injection, maximum d
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1- Patients with severe agitation and harm to themselves or others with the approval of an emergency medicine specialist2- Patients with severe agitation and harm that is not controlled by physical restraint3- Patients with severe agitation and harm aged 15 to 654- Patients with severe agitation and harm of both sexes5- No prior history of epilepsy or concomitant use of benzodiazepines or antipsychotics6- No breastfeeding or pregnancy7- Known history of allergy to benzodiazepines8- Head trauma
Exclusion criteria
Exclusion criteria: 1- Side effects of benzodiazepines 2- Shock 3- Failure to control symptoms and need for another method or medication such as antipsychotics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset of effect of midazolam and diazepam: Time in minutes until the patient calms down and stops risky behaviors. Required amount of midazolam and diazepam: Dosage of the drug that each patient receives and the number of times the drug is repeated. Duration of sedation of midazolam and diazepam: The time the patient is calm in minutes. Improvement after sedation of midazolam and diazepam: The patient's need for another action or re-administration of the same drug or a drug from a different class. Hemodynamic changes of midazolam and diazepam: Changes in blood pressure, pulse, respiratory rate, body temperature, and SPO2, which are recorded initially and the patient is monitored for cardiopulmonary function and re-recorded every 15 minutes. Short-term side effects of midazolam and diazepam: The occurrence of complications such as shock, symptoms of drug allergy, severe hemodynamic changes, pain at the injection site, and forgetfulness of events. Timepoint: Time in minutes until the patient calms down and stops risky behaviors. Method of measurement: It is calculated from the moment the drug is completely injected until the patient reaches a score of 0 to -2 on the RASS (Richmond Agitation-Sedation Scale) and recorded every 2 minutes. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Simin Najafgholian
Arak University of Medical Sciences
Outcome results
None listed