Acne.
Conditions
Interventions
Intervention 1: Intervention group: Treatment with a combination of oral isotretinoin 20 mg every other day and three sessions of PRF administered at two-week intervals. Intervention 2: Control group:
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients aged 15 to 50 years. Patients with a confirmed diagnosis of inflammatory, scar-forming facial acne. Patients who have not received any treatment for their condition during the past three months. Absence of any serious underlying systemic disease. Patient willingness and ability to comply with treatment interventions and attend all treatment sessions.
Exclusion criteria
Exclusion criteria: Development of hypersensitivity or any adverse reaction to one of the therapeutic interventions that prevents continuation of treatment. Occurrence of bacterial or viral skin diseases during the treatment period or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in inflammatory acne lesions. Timepoint: Scoring of acne lesions at baseline (prior to the initiation of the intervention) and every 14 days following each injection for up to three sessions. Method of measurement: Leeds revised acne grading.;Prevention of scar formation. Timepoint: Scoring of acne lesions at baseline (prior to the initiation of the intervention) and every 14 days following each injection for up to three sessions. Method of measurement: Goodman & Baron Quantitative Acne Scar Scoring System. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Talvari
Iran University of Medical Sciences
Outcome results
None listed