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Effect of Intranasal Oxymetazoline Spray on Intraoperative Bleeding During Rhinoplasty

Studying the effect of 0.5% oxymetazoline nasal spray on intraoperative bleeding in rhinoplasty surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20260508069292N1
Enrollment
50
Registered
2026-05-11
Start date
2026-05-22
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative bleeding during rhinoplasty.

Interventions

Intervention 1: Intervention group:Intervention group: Immediately after induction of general anesthesia and before the start of surgery, patients in this group receive one puff of 0.5% oxymetazoline

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 39 Years

Inclusion criteria

Inclusion criteria: Candidates for rhinoplasty surgery Age range of 18–39 years American Society of Anesthesiologists (ASA) physical status I or II Provision of written informed consent for participation in the study Normal preoperative nasal examination with no evidence of septal deviation or other septal/nostril pathologies

Exclusion criteria

Exclusion criteria: Known allergy or hypersensitivity to oxymetazoline History of prior nasal surgery Presence of nasal abnormalities such as septal deviation or nasal polyps Presence of renal disease

Design outcomes

Primary

MeasureTime frame
Intraoperative blood loss during rhinoplasty measured based on the total volume of blood collected in sterile gauzes and the suction reservoir. Timepoint: Intraoperatively, from the beginning of rhinoplasty to the end of surgery. Method of measurement: Intraoperative blood loss will be measured by calculating the total volume of blood collected in sterile surgical gauzes and the suction reservoir during surgery.

Secondary

MeasureTime frame
Systolic blood pressure measured during surgery. Timepoint: During surgery. Method of measurement: Systolic blood pressure will be measured using a noninvasive blood pressure monitoring device during surgery.;Diastolic blood pressure. Timepoint: During surgery. Method of measurement: Diastolic blood pressure will be measured using a noninvasive blood pressure monitoring device during surgery.;Mean arterial blood pressure. Timepoint: During surgery. Method of measurement: Mean arterial blood pressure will be measured using a noninvasive blood pressure monitoring device during surgery.;Heart rate. Timepoint: During surgery. Method of measurement: Heart rate will be measured using an electrocardiography monitoring device during surgery.;Postoperative pain intensity. Timepoint: In the recovery period after surgery. Method of measurement: Postoperative pain intensity will be measured using the Visual Analogue Scale.(VAS).;Postoperative analgesic consumption. Timepoint: During the postoperative period. Method of measurement: Total postoperative analgesic consumption will be recorded based on the amount of analgesic medications used during the postoperative period.;Surgeon satisfaction with surgical field. Timepoint: During surgery. Method of measurement: Surgeon satisfaction with the surgical field will be evaluated using a surgeon satisfaction assessment scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehrdad Masoudifar

Esfahan University of Medical Sciences

masoudifar@med.mui.ac.ir+98 313822000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026