Determining the role of high dose Methylprednisolone in the management of caustic burns of the esophagus with alkaline substances

Determining the role of high dose Methylprednisolone in the management of caustic burns of the esophagus with alkaline substances, a double-blind clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260508069286N1

Enrollment

Registered

2026-05-24

Start date

2026-06-05

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal burns due to consumption of corrosive substances in childhood. Toxic effects of corrosive alkalis and alkali-like substances

Interventions

Intervention 1: Intervention group: methylprednisolone (1g/1.73m2/day)for 3day. Intervention 2: Control group: Do not receive Methylprednisolone.

Eligibility

Sex/Gender

All

Age

1 Months to 18 Years

Inclusion criteria

Inclusion criteria: Children who developed caustic burns of the esophagus with alkaline substances Endoscopy grade 2B

Exclusion criteria

Exclusion criteria: Caustic burns grade IIa, III, I

Design outcomes

Primary

Measure	Time frame
Percentage of people with esophageal burns from caustic alkalis. Timepoint: Endoscopic evaluation at the beginning of the study and at the end of the third week. Method of measurement: Endoscopy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Zare

Shiraz University of Medical Sciences

Elhamzare@sums.ac.ir+98 71 3825 5675

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026