Hand Rejuvenation.
Conditions
Interventions
Intervention 1: Intervention groIn this group, the hand allocated to the combination treatment will receive both Fractional Carbon Dioxide laser and Q-Switched Long-Pulsed Neodymium-Doped Yttrium Alum
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 55 Years
Inclusion criteria
Inclusion criteria: They should have good overall health Participation should be voluntary They should have no prior history of skin disease
Exclusion criteria
Exclusion criteria: active skin diseases on the hands such as eczema, psoriasis, skin infections, or open wounds a history of abnormal scarring, including hypertrophic scars or keloids use of photosensitizing medications pregnancy or breastfeeding psychiatric disorders or inability to adhere to treatment protocols and follow-up a history of laser treatments or similar procedures on the hands within the past six months systemic or autoimmune diseases such as lupus or scleroderma that may interfere with skin healing severe allergies to light or materials used in the treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the clinical improvement score of hand skin wrinkles based on dermatologist assessment using a four-grade clinical improvement scale. Timepoint: Before treatment, after each treatment session, and at one month and three months following the final treatment session. Method of measurement: This variable will be assessed using both objective and subjective methods. In the objective method, standardized digital photography of both hands will be performed under fixed conditions (constant lighting, angle, distance, and uniform background). Pre- and post-treatment images will be evaluated by two independent dermatologists blinded to the treatment allocation, and the degree of improvement will be reported as a percentage ranging from 0 to 100%. Treatment response will be classified as follows: low response (0–25% improvement), mild response (25–50% improvement), moderate response (50–75% improvement), and excellent response (greater than 75% improvement). In case of disagreement greater than one grade, a third dermatologist will be consulted. In the subjective method, patient satisfaction with treatment outcomes will be recorded through a standardized direct questionnaire. In addition, adverse events including edema, pain, erythema, pruritus, blistering, hypopigmentation, hyperpigmentation, and scarring will be assessed and documented by the treating physician at each visit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHasan Sharifian dorcheh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed