Ventilator associated pneumonia(VAP). Ventilator associated pneumonia
Conditions
Interventions
Intervention 1: Intervention group: Protect drop( probiotic) made by Gostaresh Milad Pharmed , 5 drops, equivalent 1000000000 unite of Lactobacillus rhamnosus, will be administered daily. This will di
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: "PICU admission" " Mechanical ventilation for more than 48 h"
Exclusion criteria
Exclusion criteria: "Primary or secondary immune deficiency" "Acute severe pancreatitis" "Significant gastro intestinal tract injuries(ileus, bleeding,...) "No Probiotics in the past 2 weeks" "Increased risk of endovascular infections (artificial heart valve, intravenous graft, Heart trauma, history of rheumatic fever)" "Tracheostomy" "Expected extubation less than 48 hours"
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of ventilator associated pneumonia (VAP). Timepoint: Check for pneumonia at the time of intubation and then daily until extubation. Method of measurement: According to ACCP(American College Of Chest Physician) the diagnosis of VAP is given a follow: The appearance of a new or progressive infiltrate on CXR along with 2 or 3 of the following : body temperature above 38.5 or bellow 35, leukocytosis above 10000 or leucopenia bellow 3000, purulent sputum. of increased pulmonary secretion. | — |
Secondary
| Measure | Time frame |
|---|---|
| "Duration of Mechanical ventilation" , "Duration of stay in PICU" , "Duration of Antibiotic use". Timepoint: "Time of intubation and extubation" , "First day of PICU admission and day of discharge" , "Antibiotic start date for VAP and when to stop them". Method of measurement: Counting the days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarzaneh Shefai
Yazd University of Medical Sciences
Outcome results
None listed