Effect of 1%Sodium Alendronate Gel on Periodontal Lesions

Clinical and Radiographic Evaluation of The Gel Contains 1%Sodium Alendronate in the Treatment of Periodontal Lesions

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260425069158N1

Enrollment

Registered

2026-04-28

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group: Participants in this group will receive 1% Sodium Alendronate gel combined with periodontal surgery. The gel was formulated using Carbopol 934 P, Xanthan gum, Methy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diagnosis of Stage 2, Grade B periodontitis according to the new classification Presence of combined intrabony defects(three-wall or two-wall) in premolars and first or second molars of the maxilla or mandible Plaque Index less than 20% prior to surgical treatment

Exclusion criteria

Exclusion criteria: Presence of systemic diseases Need for antibiotic prophylaxis to prevent bacterial endocarditis Use of medications interfering with periodontal healing Current smoking habit Contraindications for periodontal surgery Teeth with Class II mobility Evidence of periapical pathology in the clinical or radiographic examination of the target tooth Unlikely patient compliance after initial periodontal therapy History of bleeding disorders

Design outcomes

Primary

Measure	Time frame
Clinical Attachment Level. Timepoint: Day of surgery, 6-month follow-up. Method of measurement: the Cemento-Enamel Junction (CEJ) of the target tooth is identified using a probe. The distance from the gingival margin to this area is recorded. The Clinical Attachment Level (CAL) is calculated as the difference between this value and the Probing Pocket Depth (PPD).;Gingival Index. Timepoint: Day of surgery, 6-month follow-up. Method of measurement: Based on the percentage of tooth surfaces exhibiting inflammation, with its presence and severity graded into three levels: mild, moderate, and severe.;Pocket Probing Depth. Timepoint: Day of surgery, 6-month follow-up. Method of measurement: The distance between the gingival margin and the junction of the epithelial attachment to the tooth surface, measured using a periodontal probe.	—

Measure

Time frame

Clinical Attachment Level. Timepoint: Day of surgery, 6-month follow-up. Method of measurement: the Cemento-Enamel Junction (CEJ) of the target tooth is identified using a probe. The distance from the gingival margin to this area is recorded. The Clinical Attachment Level (CAL) is calculated as the difference between this value and the Probing Pocket Depth (PPD).;Gingival Index. Timepoint: Day of surgery, 6-month follow-up. Method of measurement: Based on the percentage of tooth surfaces exhibiting inflammation, with its presence and severity graded into three levels: mild, moderate, and severe.;Pocket Probing Depth. Timepoint: Day of surgery, 6-month follow-up. Method of measurement: The distance between the gingival margin and the junction of the epithelial attachment to the tooth surface, measured using a periodontal probe.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactEhsan Shokrieh

Babol University of Medical Sciences

dr.ehsanshokrieh@gmail.com+98 914 333 7075

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026