Comparison of the Effect of Normal Saline and Ringer’s Solution Before Spinal Anesthesia on Maternal Hemodynamic Status in Elective Cesarean Section

A Comparative Evaluation of the Preoperative Administration of Normal Saline versus Ringer’s Solution on Hemodynamic Stability after Spinal Anesthesia in Candidates for Elective Cesarean Section

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260425069157N2

Enrollment

110

Registered

2026-04-29

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal anesthesia–induced hemodynamic instability (hypotension) in elective cesarean section patients. Central nervous system complications of anesthesia during labor and delivery

Interventions

ntervention Group 1: Administration of 10–15 mL/kg of 0.9% normal saline over 15–20 minutes prior to spinal anesthesia..

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Age 18 to 40 years Singleton pregnancy with a gestational age of 37 to 41 weeks Candidate for elective cesarean section under spinal anesthesia ASA physical status class I or II No history of hypersensitivity to the study medications or intravenous solutions Absence of known cardiac, renal, hepatic disorders, or hypertension No use of medications affecting blood pressure within 24 hours prior to surgery Written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Development of any maternal or fetal emergency condition before or during surgery Need to change the anesthetic technique (conversion to general anesthesia) Occurrence of an allergic reaction to the intravenous solutions Lack of patient cooperation or withdrawal from the study Severe intraoperative bleeding (more than 1000 mL)

Design outcomes

Primary

Measure	Time frame
Incidence of hypotension following spinal anesthesia. Timepoint: Blood pressure is recorded before spinal anesthesia as the baseline value, then measured every 1 minute during the first 10 minutes after spinal anesthesia, and thereafter every 3–5 minutes until delivery of the neonate. Method of measurement: Blood pressure is measured using a non-invasive blood pressure monitoring device (NIBP). Baseline blood pressure is recorded before spinal anesthesia as the average of 2–3 measurements. After spinal anesthesia, systolic blood pressure, diastolic blood pressure, and mean arterial pressure are recorded. Hypotension is defined as a systolic blood pressure less than 90 mmHg or a decrease of at least 20% from the baseline value.	—

Measure

Time frame

Incidence of hypotension following spinal anesthesia. Timepoint: Blood pressure is recorded before spinal anesthesia as the baseline value, then measured every 1 minute during the first 10 minutes after spinal anesthesia, and thereafter every 3–5 minutes until delivery of the neonate. Method of measurement: Blood pressure is measured using a non-invasive blood pressure monitoring device (NIBP). Baseline blood pressure is recorded before spinal anesthesia as the average of 2–3 measurements. After spinal anesthesia, systolic blood pressure, diastolic blood pressure, and mean arterial pressure are recorded. Hypotension is defined as a systolic blood pressure less than 90 mmHg or a decrease of at least 20% from the baseline value.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Roghayea Neisari

Oroumia University of Medical Sciences

nisari.r@umsu.ac.ir+98 44 3346 0998

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026