Knee osteoarthritis (Knee OA) is a chronic degenerative joint disease characterized by progressive destruction of articular cartilage, synovial inflammation, and subchondral bone changes. It leads to persistent pain, stiffness, and functional disability. This study specifically includes patients with grade 1, 2, or 3 knee osteoarthritis based on radiographic criteria (Kellgren-Lawrence classification).. Osteoarthritis of knee, unspecified
Conditions
Interventions
Intervention 1: Control group: Platelet-rich plasma (PRP) injection alone. Preparation method: 20 mL of venous blood is drawn with 3 mL of anticoagulant (citrate dextrose solution A or acid citrate de
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age between 30 and 70 years Diagnosis of knee osteoarthritis grade 1, 2 or 3 based on ACR clinical and radiographic criteria Knee pain for at least 6 months Visual Analogue Scale (VAS) score of at least 3 No satisfactory response to at least one conservative treatment (acetaminophen, NSAIDs, assistive devices, lifestyle modification or weight loss) At least two weeks washout period from last NSAID or corticosteroid use No history of knee injection in the last three months
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Inflammatory rheumatic diseases Severe heart disease Active skin infection at the injection site Use of immunosuppressive drugs Use of anticoagulants (warfarin or heparin) History of bleeding diathesis or current coagulation disorders Active low back pain with radiation to lower limbs History of knee surgery in the last 3 months Active infection or malignancy in the last 6 months Substance abuse Intra-articular corticosteroid injection in the last 3 months Intra-articular hyaluronic acid injection in the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain severity measured by Visual Analogue Scale (VAS). The VAS is a 10-centimeter horizontal line with 0 meaning "no pain" and 10 meaning "worst imaginable pain". Patients mark their current pain level on this line. Timepoint: Before injection (baseline), 1 month after injection, 3 months after injection. Method of measurement: Visual Analogue Scale (VAS) - a self-administered 10-centimeter horizontal line scale. The patient places a mark on the line corresponding to their perceived pain intensity. The distance from zero to the mark is measured in millimeters, yielding a score from 0 to 100 (or 0 to 10 when converted). | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical function measured by the physical function subscale of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). This subscale contains 17 questions assessing difficulty with daily activities such as walking, climbing stairs, rising from sitting, standing, bending, and household tasks. Timepoint: Before injection (baseline), 1 month after injection, 3 months after injection. Method of measurement: Persian version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function subscale. Each of the 17 questions is scored from 0 (no difficulty) to 4 (extreme difficulty). The total subscale score ranges from 0 to 68. Higher scores indicate worse physical function. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Naeiji
Tehran University of Medical Sciences
Outcome results
None listed