Coronary Artery Disease (CAD) undergoing Coronary Artery Bypass Graft surgery. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention group: Start of intervention: After successful extubation within the first 24 hours post-surgery and confirmation of hemodynamic stability.Duration: From the time of clinical stabilizatio
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 45 and 65 years Absence of cardiac pacemaker No arrhythmia or unstable angina Absence of dyspnea or abnormal respiratory signs Ability to provide written informed consent
Exclusion criteria
Exclusion criteria: Orthopedic disorders limiting participation in rehabilitation Significant dietary changes within the last month Gastrointestinal diseases such as IBD, IBS, chronic diarrhea, colitis, or untreated H. pylori infection Probiotic or prebiotic intake within the last four weeks Oral or intravenous antibiotic use within the last four weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Zonulin. Timepoint: Before and after cardiac rehabilitation intervention. Method of measurement: ELISA.;I-FABP. Timepoint: Before and after cardiac rehabilitation intervention. Method of measurement: ELISA.;Blood microbiome. Timepoint: **Before and after cardiac rehabilitation intervention**. Method of measurement: Quantitative polymerase chain reaction. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Before and after rehabilitation intervention. Method of measurement: PHQ-9 questionnaire.;Functional capacity. Timepoint: Before and after rehabilitation intervention. Method of measurement: Six-minute walk test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Zamaemifard
University of Tehran
Outcome results
None listed