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Comparison of antibacterial effects of nano silver particles and calcium hydroxide in root canal treatment of necrotic teeth: A randomized controlled trial clinical study

Comparison of antibacterial effects of nano silver particles and calcium hydroxide in root canal treatment of necrotic teeth: A randomized controlled trial clinical study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20260418069092N1
Enrollment
42
Registered
2026-05-19
Start date
2026-05-26
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Single-rooted maxillary anterior teeth with pulp necrosis and without acute symptoms. Necrosis of pulp

Interventions

Intervention 1: Intervention group: In this group, after root canal preparation using a crown-down technique with a rotary system (4% taper, 300 rpm, 2-3 N.cm torque) and irrigation with 1.5% sodium h

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 65 years, with general good health and no systemic diseases. Maxillary anterior single-canal teeth diagnosed with pulp necrosis (no response to pulp vitality tests such as cold test and EPT). No response to percussion and palpation tests due to standardization, and the tooth must be capable of isolation with a rubber dam.

Exclusion criteria

Exclusion criteria: Pregnant or breastfeeding women Patients with specific systemic diseases Patients with swelling (intraoral or extraoral) were excluded for the purpose of study standardization.

Design outcomes

Primary

MeasureTime frame
Bacterial load. Timepoint: Before and after the intervention. Method of measurement: Percentage reduction of colony-forming units (CFU/mL) in the second sampling (S2) compared to the first sampling (S1).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoroush Saleh jahromi

Birjand University of Medical Sciences

soroush.s@bums.ac.ir+98 56 3239 5054

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026