The Effect of Aromatherapy with Orange and Peppermint Scents on Reducing Nausea, Vomiting, and Anxiety in Children Undergoing Chemotherapy

Comparison of the Effect of Aromatherapy with Orange and Peppermint Essential Oils on Nausea, Vomiting, and Anxiety in Children with Cancer Undergoing Chemotherapy Referred to Hospitals and Clinics Affiliated with Shiraz University of Medical Sciences

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260414069075N1

Enrollment

120

Registered

2026-05-05

Start date

2026-05-24

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Nausea and Vomiting. Condition 2: Anxiety. Nausea and vomiting Anxiety disorder due to known physiological condition

Interventions

Intervention 1: Intervention group: In the orange essential oil aromatherapy group, in addition to routine ward care, aromatherapy will be administered using two drops of orange essential oil placed

Eligibility

Sex/Gender

All

Age

9 Years to 12 Years

Inclusion criteria

Inclusion criteria: Children aged 9–12 years of both genders Ability to understand and speak Persian No history of hypersensitivity, allergic rhinitis, and asthma or known respiratory problems Having a healthy sense of smell Receiving chemotherapy with drugs that have moderate to severe emetogenic potential Not having diseases that lead to vomiting The patient’s ability to determine the severity of nausea, vomiting, and anxiety according to the protocol No history of psychological problems or anxiety disorders according to self-report No use of sedative or anxiolytic drugs A history of receiving at least one session of chemotherapy, and reporting nausea and vomiting after that

Exclusion criteria

Exclusion criteria: Lack of willingness of the child and parents to perform the intervention Sensitivity to herbal essential oils Use of other complementary medicine methods

Design outcomes

Primary

Measure	Time frame
Nausea score on the Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Adapted Rhodes Index of Nausea and Vomiting for Pediatric.;Vomiting score on the Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Adapted Rhodes Index of Nausea and Vomiting for Pediatric.;Anxiety score on the Spielberger's State-Trait Anxiety Inventory for Children. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Spielberger's State-Trait Anxiety Inventory for Children.	—

Measure

Time frame

Nausea score on the Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Adapted Rhodes Index of Nausea and Vomiting for Pediatric.;Vomiting score on the Adapted Rhodes Index of Nausea and Vomiting for Pediatric. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Adapted Rhodes Index of Nausea and Vomiting for Pediatric.;Anxiety score on the Spielberger's State-Trait Anxiety Inventory for Children. Timepoint: Before intervention, 12 and 24 hours after chemotherapy. Method of measurement: Spielberger's State-Trait Anxiety Inventory for Children.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNarges Rahimi

Shiraz University of Medical Sciences

nargesrahimi.hr@gmail.com+98 71 3647 4254

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026