Isoflurane vs. Propofol–Remifentanil in Elective Cholecystectomy

A Comparative Study of the Effects of Isoflurane versus Infusion of Propofol Combined with Remifentanil on Hemodynamics and Arterial Oxygen Saturation in Patients Undergoing Elective Cholecystectomy: A Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260412069062N1

Enrollment

Registered

2026-04-25

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholelithiasis. Cholelithiasis

Interventions

Intervention 1: Intervention group: Group A (Isoflurane group):Maintenance of anesthesia will be performed with Isoflurane at a concentration of 1–1.5% delivered via a calibrated vaporizer. All other

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Candidates for laparoscopic cholecystectomy American Society of Anesthesiologists (ASA) Physical Status Class I and II

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding History of substance abuse

Design outcomes

Primary

Measure	Time frame
Systolic Blood Pressure. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Diastolic Blood Pressure. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Mean Arterial Pressure. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Oxygen saturation percentage. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Heart rate. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Respiratory rate. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.	—

Measure

Time frame

Systolic Blood Pressure. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Diastolic Blood Pressure. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Mean Arterial Pressure. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Oxygen saturation percentage. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Heart rate. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.;Respiratory rate. Timepoint: Before induction of anesthesia; at 5 and 30 minutes after induction; after extubation; and upon admission to the recovery room. Method of measurement: Using standard anesthesia monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Mohammadhoseini

Yasouj University of Medical Sciences

Mohamadhoseini.f@yums.ac.ir+98 74 3323 5153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026