Malignant neoplasm of connective and soft tissue of head, face, and neck. http://apps.who.int/classifications/icd10/browse/2010/en
Conditions
Interventions
Intervention 1: Intervention group: After excision of the malignant lesion and before flap placement, the surgical site will be irrigated with a 3% TXA solution, and a TXA-soaked gauze will be applied
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age = 18 years Patients with basal cell carcinoma in the head region, including the face and scalp Reconstructive surgery using flap technique
Exclusion criteria
Exclusion criteria: Patients with a BMI = 35 Patients who are smokers Pregnant patients Patients with an American Society of Anesthesiologists (ASA) score greater than 3 Patients taking anticoagulant or antiplatelet medications Patients with uncontrolled comorbidities Patients with a history of receiving neoadjuvant therapy Patients with a history of prior surgery in the head region Patients with a previous history of thromboembolic events, autoimmune diseases, or hematologic disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative ecchymosis. Timepoint: Patients will be evaluated for outcomes at 24 hours postoperatively, as well as at 7 days, 28 days, and 3 months after surgery. Method of measurement: Examination of the surgical site and assessment of the occurrence ecchymosis (or not). | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss; other postoperative complications (hematoma, flap ischemia/necrosis, surgical site infection, thromboembolic events, hypertrophic scar, keloid); the need for reoperation; length of hospital stay (days); and hospital readmission will be assessed. The surgical scar status will be evaluated at the end of the 3-month follow-up. Timepoint: Patients will be evaluated for outcomes at 24 hours postoperatively, as well as at 7 days, 28 days, and 3 months after surgery. Method of measurement: The Boezzart scale will be used to assess the intraoperative bleeding. Postoperative complications will be evaluated through patient examination and inspection of the surgical site to determine the presence or absence of any events. At the end of the 3-month follow-up, the following questionnaire will be used to assess the surgical scar condition: the Patient and Observer Scar Assessment Scale (POSAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactReza Sharifi
Mashhad University of Medical Sciences
Outcome results
None listed