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Studying the effect of probiotic supplementation in treatment of infertility

Studying the effect of probiotic supplementation in infertile couples on pregnancy rate in intrauterine insemination

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20260411069042N1
Enrollment
96
Registered
2026-04-21
Start date
2026-05-10
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Female infertility associated with male factors

Interventions

Intervention 1: Intervention group: Couples According to the prescription of the Infertility Fellowship, the intervention group receives a supplement of one capsule of oral probiotic Lactofem (6 weeks

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Have an acceptable criterion for intrauterine insemination Females age 20-40 and males age 25-55 Iranian infertile couple and candidate for performing IUI according to the opinion of the infertility fellowship

Exclusion criteria

Exclusion criteria: chronic disease such as diabetes, autoimmune disease, and cancer recent use of antibiotics history of sensitivity to probiotics and dairy products

Design outcomes

Primary

MeasureTime frame
Pregnancy rate. Timepoint: 16days after intrauterine insemination. Method of measurement: measurement of bhcg level in serum.

Secondary

MeasureTime frame
Sperm morphology. Timepoint: Before the start of intervention and on day 42 after consumption of probiotic supplement. Method of measurement: semen analysis.;Progressive motility of sperm. Timepoint: Before the start of intervention and on day 42 after consumption of probiotic supplement. Method of measurement: semen analysis.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Moshfeghy

Shiraz University of Medical Sciences

moshfeghiz@sums.ac.ir+98 71 3647 4254

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026