Effect of a Herbal Preparation Containing Plantain, Damask Rose, and Marshmallow on the Symptoms of Patients with Atopic Dermatitis

The effecte herbal product of Plantago major and Rosa damascena and Althaea officinalis on the clinical symptoms of patients with atopic dermatitis : Clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260406069024N1

Enrollment

Registered

2026-04-08

Start date

2026-05-10

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis. Atopic dermatitis

Interventions

Intervention 1: Intervention in this study consists of a herbal ointment containing hydroalcoholic extracts of Plantago major (plantain), Rosa damascena (damask rose), and Althaea officinalis (marshma

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with mild to moderate atopic dermatitis (based on the SCORAD index with a score below 50).

Exclusion criteria

Exclusion criteria: Presence of psoriasis or other skin diseases. Any known previous hypersensitivity to any component of the prepared medication. Bacterial infection or concomitant systemic disease (except asthma and allergic rhinitis). Use of antihistamines or corticosteroids during the past three weeks.

Design outcomes

Primary

Measure	Time frame
Mean clinical symptom score based on the SCORAD index. Timepoint: 4 weeks. Method of measurement: Lichenification = Thickening of the skin with prominent skin markings resembling tree bark (lichen) — SCORAD criterion.Erythema = Redness of the skin — SCORAD criterion.Papulation (Papules) = Small, raised, solid skin lesions — SCORAD criterion.Dryness = Reduced skin moisture and elasticity — SCORAD criterion.Pruritus (Itching) = A sensation that provokes the urge to scratch the skin — SCORAD criterion.Oozing = Secretion or exudation of fluid from skin lesions — SCORAD criterion.Crusting = Formation of a dry layer or crust on the skin surface — SCORAD criterion.Scratch marks (Excoriations) = Skin abrasions caused by scratching — SCORAD criterion.Extent of affected area = The percentage of body surface area involved with atopic dermatitis lesions — SCORAD criterion.Sleep disturbance = Difficulty falling asleep, frequent nighttime awakenings, or reduced sleep quality due to itching or skin discomfort from atopic dermatitis during the three nights prior to completing the form — SCORAD criterion.;Mean pruritus (itching) score based on the VAS scale. Timepoint: 4 weeks. Method of measurement: Visual Analogue Scale questionnaire for assessment of itching severity.	—

Measure

Time frame

Mean clinical symptom score based on the SCORAD index. Timepoint: 4 weeks. Method of measurement: Lichenification = Thickening of the skin with prominent skin markings resembling tree bark (lichen) — SCORAD criterion.Erythema = Redness of the skin — SCORAD criterion.Papulation (Papules) = Small, raised, solid skin lesions — SCORAD criterion.Dryness = Reduced skin moisture and elasticity — SCORAD criterion.Pruritus (Itching) = A sensation that provokes the urge to scratch the skin — SCORAD criterion.Oozing = Secretion or exudation of fluid from skin lesions — SCORAD criterion.Crusting = Formation of a dry layer or crust on the skin surface — SCORAD criterion.Scratch marks (Excoriations) = Skin abrasions caused by scratching — SCORAD criterion.Extent of affected area = The percentage of body surface area involved with atopic dermatitis lesions — SCORAD criterion.Sleep disturbance = Difficulty falling asleep, frequent nighttime awakenings, or reduced sleep quality due to itching or skin discomfort from atopic dermatitis during the three nights prior to completing the form — SCORAD criterion.;Mean pruritus (itching) score based on the VAS scale. Timepoint: 4 weeks. Method of measurement: Visual Analogue Scale questionnaire for assessment of itching severity.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Hushang Malamiri

Yazd University of Medical Sciences

hushanghamed@gmail.com+98 35 3223 8916

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026