Evaluation of the albumin infusion compared with branched-chain amino acids in patients with acute heart failure

Evaluation of the albumin infusion compared with branched-chain amino acids in patients with acute heart failure: a randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260224068932N1

Enrollment

Registered

2026-02-26

Start date

2026-03-06

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure. Heart failure

Interventions

Intervention 1: Intervention group 1: Patients receive albumin at a dose of 20 g per day for two consecutive days. Intervention 2: Intervention group 2: Patients receive branched-chain amino acids (BC

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients 18 years or older with any type of acute heart failure with a serum albumin level less than 3.5 mg/dl are standard candidates for diuretics

Exclusion criteria

Exclusion criteria: Patients with nephritic syndrome Patients with liver cirrhosis Patients with congenital abnormalities of amino acid metabolism Patients with severe ventricular arrhythmia Patients with mechanical ventilation Patients with severe infection

Design outcomes

Primary

Measure	Time frame
Clinical signs. Timepoint: Two weeks and four weeks after hospitalization. Method of measurement: Right-sided heart failure symptoms: Elevated jugular venous pressure (>8 cm), jugular venous reflux, hepatomegaly, and bilateral lower-extremity edema. Left-sided heart failure symptoms: Dyspnea, dyspnea on exertion, orthopnea, third heart sound (S3), pulmonary rales, and paroxysmal nocturnal dyspnea (PND).;Echocardiographic variables. Timepoint: Two weeks and four weeks after hospitalization. Method of measurement: Right-sided heart findings: Inferior vena cava (IVC) collapse greater than 50% and inspiratory IVC diameter less than 21 mm. Left-sided heart findings: Mitral inflow E-wave velocity >50, lateral E/e’ ratio >12, deceleration time <130 ms, and pulmonary vein S/D ratio <1.	—

Measure

Time frame

Clinical signs. Timepoint: Two weeks and four weeks after hospitalization. Method of measurement: Right-sided heart failure symptoms: Elevated jugular venous pressure (>8 cm), jugular venous reflux, hepatomegaly, and bilateral lower-extremity edema. Left-sided heart failure symptoms: Dyspnea, dyspnea on exertion, orthopnea, third heart sound (S3), pulmonary rales, and paroxysmal nocturnal dyspnea (PND).;Echocardiographic variables. Timepoint: Two weeks and four weeks after hospitalization. Method of measurement: Right-sided heart findings: Inferior vena cava (IVC) collapse greater than 50% and inspiratory IVC diameter less than 21 mm. Left-sided heart findings: Mitral inflow E-wave velocity >50, lateral E/e’ ratio >12, deceleration time <130 ms, and pulmonary vein S/D ratio <1.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Montazeri

Kermanshah University of Medical Sciences

nafis_mont@yahoo.com+98 83 3835 8943

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026