Comparison of two methods for preserving jawbone after the extraction of several adjacent teeth

Comparative Efficacy of Hyaluronic Acid-Enriched Allograft for Alveolar Ridge Preservation in Multiple Adjacent Extraction Sites: A Randomized Controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260216068884N1

Enrollment

Registered

2026-03-15

Start date

2026-03-06

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth extraction of multiple adjacent teeth and subsequent alveolar bone resorption.

Interventions

Intervention 1: Intervention group: Allograft enriched with Hyaluronic Acid: After tooth extraction, the socket will be filled with a mixture of allograft particles and hyaluronic acid solution (Perfe

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients requiring the extraction of multiple adjacent teeth (two or three teeth, from the right second premolar to the left second premolar region). Aged at least 18 years. Absence of severe systemic diseases that may affect bone healing (e.g., uncontrolled diabetes, severe osteoporosis). No use of medications that affect bone healing (e.g., bisphosphonates). Absence of acute periapical infection or fistula in the teeth to be extracted. Sockets with less than 50% buccal bone dehiscence after tooth extraction.

Exclusion criteria

Exclusion criteria: Patients who do not comply with treatment instructions during the study. Patients who withdraw from the study for personal or medical reasons Smokers. Patients with poor oral hygiene or unwillingness to follow hygiene instructions. Individuals belonging to vulnerable groups, including pregnant women or those lacking legal capacity or mental ability to provide informed consent.

Design outcomes

Primary

Measure	Time frame
Changes in alveolar ridge dimensions (width and height) measured by CBCT. Timepoint: Baseline (before extraction) and 3 months after extraction. Method of measurement: Cone Beam Computed Tomography (CBCT) with image superimposition and analysis using Romexis software.	—

Secondary

Measure	Time frame
Changes in soft tissue contour (volume) of the alveolar ridge. Timepoint: Baseline (before extraction) and 3 months after extraction. Method of measurement: Digital scanning and superimposition of STL files using analysis software.;Postoperative pain intensity. Timepoint: Daily for the first week after extraction. Method of measurement: Visual Analogue Scale (VAS) from 0 to 10.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGhazal Soleimani

Tehran University of Medical Sciences

ghazal.soleimani73@gmail.com+98 21 8835 1255

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026