Male Idiopathic Infertility. Poisoning by, adverse effect of and underdosing of iminostilbenes
Conditions
Interventions
Intervention group: The intervention includes daily oral administration of letrozole 2.5 mg for the first group and tamoxifen 20 mg for the second group for three months. Medications are taken by pati
Sponsors
Zahedan University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Idiopathic infertility (=1 year) Age 20-50 years =2 semen abnormalities (WHO criteria) Normal or mildly elevated FSH Healthy, non-pregnant wife No fertility-affecting medications (past 3 months) Signed informed consent
Exclusion criteria
Exclusion criteria: Infertility with known cause (e.g., varicocele, obstruction, infection) Azoospermia (no sperm) History of vasectomy or groin surgery Hypogonadotropic hypogonadism (low FSH/LH) Chromosomal abnormalities (e.g., Klinefelter syndrome) Systemic diseases (diabetes, hypothyroidism, malignancy) Smoking, alcohol, or drug abuse Hypersensitivity to Letrozole or Tamoxifen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm parameters. Timepoint: Before and after treatment (baseline and 3 months). Method of measurement: Semen analysis (WHO 2021) and ELISA.;Hormonal profile. Timepoint: Baseline and 3 months post-treatment. Method of measurement: Measurement of FSH, LH, testosterone, and estradiol levels in blood samples using ELISA method.;Testosterone/estradiol ratio. Timepoint: Baseline and end of month 3. Method of measurement: Calculation of testosterone (ng/dL) to estradiol (pg/mL) ratio from blood test results. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Khorasani genareh
Zahedan University of Medical Sciences
Outcome results
None listed