Spastic Stroke. Spastic hemiplegic cerebral palsy
Conditions
Interventions
Intervention 1: Intervention group: The group receiving transcranial magnetic stimulation of the motor area of ??the brain (M1-iTBS). To stimulate the M1, iTBS will apply over the motor hotspot of the
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with Stroke Aged 40 to 75 Years At Least 6 Months And No More Than 2 Years Have Passed Since The Onset Of Stroke Unilateral Ischemic Or Hemorrhagic Stroke Confirmed By CT Scan Or MRI Presence Of Spasticity In The Wrist Flexor Muscles With A Score Greater Than 1 On The Modified Modified Ashworth Scale (MMAS) No History Of Botulinum Toxin Injection Within The Past 6 Months Adequate Cognitive Ability To Complete The Assessment Procedures And Treatment Protocol
Exclusion criteria
Exclusion criteria: Patients With Cerebellar Or Brainstem Lesions Presence Of Severe Psychiatric Or Communication Disorders That Interfere With Cooperation In The Study Process Progressive Neurological Diseases Such As Neurodegenerative Disorders And Active Medical Conditions Including Infections Presence Of Concomitant Neurological Diseases Or Orthopedic Disorders Affecting Upper Limb Function Individuals With Contraindications To Intermittent Theta Burst Stimulation (iTBS) Such As History Of Seizure, Cerebral Aneurysm, Intracranial Metal Implants, Cardiac Pacemaker, Or Pregnancy Inability To Understand Or Comply With The Study Procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Motor Cortex Excitability Of The Affected Hemisphere Based On Resting Motor Threshold (RMT) Of The Extensor Carpi Radialis Brevis Muscle. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Transcranial Magnetic Stimulation Device.;Amplitude of Motor Evoked Potential (MEP) Responses of the Extensor Carpi Radialis Brevis Muscle in the Affected Hemisphere. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Surface Electromyography.;Evoked Silent Period (ESP) of the Extensor Carpi Radialis Brevis Muscle in the Affected Hemisphere. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Transcranial Magnetic Stimulation Device.;Wrist Flexor Muscle Spasticity. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Modified Modified Ashworth Scale.;Wrist flexor and extensor muscle activity recorded as Root Mean Square (RMS) of the sEMG signal in active and passive movements. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Surface Electromyography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Stroke-specific Quality of Life Questionnere.;Upper Limb Function. Timepoint: Before The Intervention, 10 Days After The Start Of The Intervention, And One Month After The End Of The Intervention. Method of measurement: Fugl-Meyer Assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMona Ramezani
Semnan University of Medical Sciences
Outcome results
None listed