The effect of submaximal aerobic exercise on cardiac factors in patients with thalassemia major

The effect of 12 weeks of submaximal aerobic training (swimming) on ??aerobic capacity and heart rate variability in girls with thalassemia major

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260209068813N1

Enrollment

Registered

2026-02-28

Start date

2025-09-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac factors in thalassemia major patients. Beta thalassemia

Interventions

Intervention group: Thalassemia major exercise (3 days a week for 12 weeks of submaximal aerobic exercise and water rehabilitation), exercise duration will range from 20 to 60 minutes, and the exercis

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Women with thalassemia major Women with thalassemia major should have no history of heart disease

Exclusion criteria

Exclusion criteria: Patients are able to do exercise Non-smoking by the aforementioned patients Individuals with neuropathy, cerebrovascular or ocular disorders, cardiorespiratory failure, high blood pressure, or taking medications that affect resting heart rate were excluded from the study.

Design outcomes

Primary

Measure	Time frame
Detailed changes in HRV indices (SDNN, RMSSD, 5SDANN, PNN50 HF, LF, (VLF, LF / HF) and echocardiographic indices (LV- AO- LA- RV- FS- EF- MPI- PWTS-PWTD- IVSTS- IVSTD) from the beginning of the study to the end of the intervention. Timepoint: HRV, echocardiography, and blood factors were measured in the pre-test, one week after the last blood transfusion, and in the post-test, 48 hours after the end of the training intervention. Method of measurement: HRV was measured using a Holter monitoring device, and cardiac structure and function were measured using echocardiography.	—

Measure

Time frame

Detailed changes in HRV indices (SDNN, RMSSD, 5SDANN, PNN50 HF, LF, (VLF, LF / HF) and echocardiographic indices (LV- AO- LA- RV- FS- EF- MPI- PWTS-PWTD- IVSTS- IVSTD) from the beginning of the study to the end of the intervention. Timepoint: HRV, echocardiography, and blood factors were measured in the pre-test, one week after the last blood transfusion, and in the post-test, 48 hours after the end of the training intervention. Method of measurement: HRV was measured using a Holter monitoring device, and cardiac structure and function were measured using echocardiography.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Nazem

The University of bu-ali Sina

farzadnazem2@gmail.com+98 81 3140 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026