Bipolar disorder.
Conditions
Interventions
Intervention 1: Intervention group: Received one capsule of Gerilact® daily for six weeks(5) (from the start of ECT to four weeks after its completion). Each capsule contains a combination of probioti
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 45 years Diagnosis of bipolar disorder in the phase of mania type I or II Under treatment with ECTat least six sessions Not having neurological or severe psychotic diseases that prevent the treatment of cognitive tests No history of probiotics or synbiotics in the last three months. Absence of Hypothyroid Disease Lack of lithium treatment at the beginning of the study Non-use of illicit drugs and substitute compounds Written informed consent from the patient or legal guardian
Exclusion criteria
Exclusion criteria: Gastrointestinal or allergic side effects of Geri Lact® supplement The duration of ECT is more than six sessions Lack of cooperation in assessments due to psychosis or severe agitation Premature termination of ECT or change in treatment protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Attention and Orientation. Timepoint: 1. Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Memory. Timepoint: 1.Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Language. Timepoint: 1.Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Verbal Fluency. Timepoint: 1.Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Visuospatial Abilities. Timepoint: 1.Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Memory Composite Index. Timepoint: 1.Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Global Cognitive Fluidity Index. Timepoint: 1.Before starting treatment, hypersonial 2.24 hours after the sixth session of ECT (Post-ECT)3.One month after the end of the ECT course. Method of measurement: The average score of the total cognitive test of Adenbrooke’s Cognitive Examination.;Medication group. Timepoint: From the start of ECT to four | — |
Secondary
| Measure | Time frame |
|---|---|
| Age. Timepoint: The beginning of the study. Method of measurement: Checklist.;Sex. Timepoint: The beginning of the study. Method of measurement: Checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Mirza Sharafi
Arak University of Medical Sciences
Outcome results
None listed