The effect of vitamin C, vitamin E, and dexamethasone on the outcome of patients with pulmonary contusion.

Studying the effect of vitamin C, vitamin E, and dexamethasone on the outcome of patients with pulmonary contusion following major blunt chest trauma

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260127068674N1

Enrollment

Registered

2026-03-16

Start date

2026-03-06

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Contusion. Contusion of lung

Interventions

Intervention 1: Intervention group: Vitamin C (500 mg in 50 ml of normal saline) and vitamin E (100 international units in 50 ml of emulsion) intravenously daily and dexamethasone 0.2 mg/kg body weigh

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Having a major lung contaminant and confirming it with a radiograph or CT scan TTSS score above 7

Exclusion criteria

Exclusion criteria: Penetrating trauma receiving oral or inhaled corticosteroids two weeks before study entry need for major emergency surgical interventions such as brain, abdominal, and major orthopedic surgery (hip, femur fractures) patients with opiate addiction chronic obstructive pulmonary disease asthma pulmonary edema thromboembolic effects in long bone fractures pneumonia respiratory distress syndrome known diabetes

Design outcomes

Primary

Measure	Time frame
Final Outcome (Death/Discharge). Timepoint: End of 7th day after the intervention initiation. Method of measurement: Final status of patient will be evaluated.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Khaleghi Arani

Kashan University of Medical Sciences

J.khaleghi@kaums.ac.ir+98 31 5558 9905

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026