The effect of vancomycin powder on bone fusion in fixation surgery in patient with degenerative thoracolumbar spinedisease

The effect of vancomycin powder on bone fusion in fixation surgery in patient with degenerative thoracolumbar spinedisease: A randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260124068648N1

Enrollment

Registered

2026-02-01

Start date

2024-06-27

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Effect of Vancomycin Powder on Bone Fusion in Thoracolumbar Fixation Surgery.

Interventions

Intervention 1: Intervention group: The application of 2 grams of vancomycin powder at the thoracolumbar surgical site.autorenewthumb_upthumb_down. Intervention 2: Control group: No vancomycin powder

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age between 30 and 60 years Degenerative or isthmic spondylolisthesis

Exclusion criteria

Exclusion criteria: Sensitivity (allergy) to vancomycin Previous history of spine surgery CSF leak (dural tearing) Osteoporosis with a T-score < –2.5 Immunodeficiency Use of medications such as prednisolone Diabetes mellitus (DM) or rheumatoid arthritis (RA)

Design outcomes

Primary

Measure	Time frame
Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale,. Timepoint: Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale,. Method of measurement: Measurement of pain intensity using the Visual Analog Scale (VAS) score,.;Bone fusion will be evaluated one year after surgery by computed tomography (CT). Timepoint: bone fusion will be evaluated one year after surgery by computed tomography (CT). Method of measurement: assessment of bone fusion using the Hounsfield unit scale.	—

Measure

Time frame

Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale,. Timepoint: Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale,. Method of measurement: Measurement of pain intensity using the Visual Analog Scale (VAS) score,.;Bone fusion will be evaluated one year after surgery by computed tomography (CT). Timepoint: bone fusion will be evaluated one year after surgery by computed tomography (CT). Method of measurement: assessment of bone fusion using the Hounsfield unit scale.

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Secondary

Measure	Time frame
Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale. Timepoint: Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale. Method of measurement: Measurement of pain intensity using the Visual Analog Scale (VAS) score.;Bone fusion will be evaluated one year after surgery by computed tomography (CT). Timepoint: bone fusion will be evaluated one year after surgery by computed tomography (CT). Method of measurement: assessment of bone fusion using the Hounsfield unit scale.	—

Measure

Time frame

Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale. Timepoint: Pain intensity will be assessed at 3-month intervals using a 0–10 numeric rating scale. Method of measurement: Measurement of pain intensity using the Visual Analog Scale (VAS) score.;Bone fusion will be evaluated one year after surgery by computed tomography (CT). Timepoint: bone fusion will be evaluated one year after surgery by computed tomography (CT). Method of measurement: assessment of bone fusion using the Hounsfield unit scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfrashteh masoud

Shiraz University of Medical Sciences

afrashtehmasoud1371@gmail.com+98 71 3231 4287

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026