Effect of physical exercise and caloric restriction on the inflammatory processes and pathogenesis of the cardiovascular system

Effect of exercise volume and caloric restriction on the ADMA and LOX-1 levels in obese and overweight sedentary women

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260123068640N1

Enrollment

Registered

2026-03-16

Start date

2026-04-20

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and Obesity. Overweight and Obesity

Interventions

Intervention 1: First intervention group: Exercise volume 1 (16 sessions in eight weeks, two sessions per week, calorie consumption per session 500 calories) + caloric restriction 1 (caloric restricti

Eligibility

Sex/Gender

Female

Age

19 Years to 40 Years

Inclusion criteria

Inclusion criteria: Body mass index between 27 and 35 kg/m2 No underlying (e.g., diabetes), cardiovascular, or musculoskeletal diseases Lack of pregnancy or breastfeeding No-use of specific medication

Exclusion criteria

Exclusion criteria: Having physical injury/problem restricting physical exercise Being under treatment or following a special diet

Design outcomes

Primary

Measure	Time frame
Concentration of Asymmetric Dimethylarginine (ADMA) in blood serum. Timepoint: Immediately before and after 8-week intervention. Method of measurement: ELISA kit based on the laboratory protocols.;Concentration of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 (LOX-1) in blood serum. Timepoint: Immediately before and after 8-week intervention. Method of measurement: ELISA kit based on the laboratory protocols.;Body mass index based on the formula (weight in kilograms divided by square of height in meters). Timepoint: Immediately before and after 8-week intervention. Method of measurement: Weighing scale and stadiometer (SECA, Germany).;Body composition (muscle mass, fat mass, visceral fat mass, waist-to-hip ratio). Timepoint: Immediately before and after 8-week intervention. Method of measurement: Body composition analyzer device (InBody 270).;Blood lipid profile using colorimetric assay. Timepoint: Immediately before and after 8-week intervention. Method of measurement: Colorimetric assay based on the laboratory protocols.	—

Measure

Time frame

Concentration of Asymmetric Dimethylarginine (ADMA) in blood serum. Timepoint: Immediately before and after 8-week intervention. Method of measurement: ELISA kit based on the laboratory protocols.;Concentration of Lectin-like Oxidized Low-density Lipoprotein Receptor-1 (LOX-1) in blood serum. Timepoint: Immediately before and after 8-week intervention. Method of measurement: ELISA kit based on the laboratory protocols.;Body mass index based on the formula (weight in kilograms divided by square of height in meters). Timepoint: Immediately before and after 8-week intervention. Method of measurement: Weighing scale and stadiometer (SECA, Germany).;Body composition (muscle mass, fat mass, visceral fat mass, waist-to-hip ratio). Timepoint: Immediately before and after 8-week intervention. Method of measurement: Body composition analyzer device (InBody 270).;Blood lipid profile using colorimetric assay. Timepoint: Immediately before and after 8-week intervention. Method of measurement: Colorimetric assay based on the laboratory protocols.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHosna Hatami

Tehran University

hatami.hosna@ut.ac.ir+98 21 8835 1730

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026