Investigating the Effect of Vitamin B12 on Improving Acute Kidney Injury Function in Children

Studying the effect of vitamin B12 on the recovery process and performance of all children and adolescents hospitalized in Amirkabir Hospital with acute kidney injury

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260120068619N1

Enrollment

Registered

2026-01-28

Start date

2026-02-09

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of vitamin B12 on acute kidney injury in children.. Acute kidney failure

Interventions

Intervention 1: Intervention group: In addition to standard hospital care, intravascular injection of vitamin B12 in a daily dose of 250 micrograms will be administered for 3 days, and on the third da

Eligibility

Sex/Gender

All

Age

2 Years to 18 Years

Inclusion criteria

Inclusion criteria: Hospitalized children aged 2 to 18 years with acute kidney injury at AmirKabir Hospital in Arak

Exclusion criteria

Exclusion criteria: Chronic kidney disease, parents' dissatisfaction with recent vitamin B12 intake, liver disease.

Design outcomes

Primary

Measure	Time frame
Serum creatinine. Timepoint: Three days after starting the medication. Method of measurement: Blood sampling and conducting tests.;BUN (Blood Urea Nitrogen). Timepoint: Three days after starting the medication. Method of measurement: Blood sampling and conducting tests.;Glomerular filtration rate. Timepoint: Three days after starting the medication. Method of measurement: Based on the calculation formula.	—

Measure

Time frame

Serum creatinine. Timepoint: Three days after starting the medication. Method of measurement: Blood sampling and conducting tests.;BUN (Blood Urea Nitrogen). Timepoint: Three days after starting the medication. Method of measurement: Blood sampling and conducting tests.;Glomerular filtration rate. Timepoint: Three days after starting the medication. Method of measurement: Based on the calculation formula.

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Secondary

Measure	Time frame
Hemoglobin. Timepoint: Hospitalization start. Method of measurement: Blood sampling and conducting tests.;Clinical symptoms associated with vitamin B12 deficiency. Timepoint: Hospitalization start. Method of measurement: Medical history and clinical examination.;Hospital stay. Timepoint: At the time of patient discharge. Method of measurement: Review of the patient's medical record.;Clinical recovery process. Timepoint: During hospitalization. Method of measurement: Counting the days of hospitalization.	—

Measure

Time frame

Hemoglobin. Timepoint: Hospitalization start. Method of measurement: Blood sampling and conducting tests.;Clinical symptoms associated with vitamin B12 deficiency. Timepoint: Hospitalization start. Method of measurement: Medical history and clinical examination.;Hospital stay. Timepoint: At the time of patient discharge. Method of measurement: Review of the patient's medical record.;Clinical recovery process. Timepoint: During hospitalization. Method of measurement: Counting the days of hospitalization.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahmoud Hasoumi

Arak University of Medical Sciences

mhasoumi@muq.ac.ir+98 25 3292 5046

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026