Investigating the association between exposure to air pollution & metabolites

Investigating the association between short-term exposure to ambient Particulate Matter (PM2.5 and PM10) and changes in metabolomic profiles in healthy young adults in Tehran, with and without the use of face masks: A randomized crossover trial study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260119068617N1

Enrollment

Registered

2026-05-06

Start date

2026-05-23

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

changes in metabolomic profiles.

Interventions

Intervention group: 40 healthy young adults who use respiratory face masks(N95 with exhalation valve) for 4 hours while doing light physical activity( walking alongside streets(preassigned routes))whe

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Residing in Tehran in the study period Age: 18-35 years old Participants should be healthy( this criteria is validated by the physician's observations

Exclusion criteria

Exclusion criteria: Having the history of cardiovascular or respiratory or metabolic diseases Smoking Alcohol consumption Consuming the drugs that affect the metabolism

Design outcomes

Primary

Measure	Time frame
Systolic Blood Pressure( SBP) & Diastolic Blood Pressure(DBP). Timepoint: Before blood sampling( before & after each exposure session). Method of measurement: Using a Beurer blood pressure monitor.	—

Secondary

Measure	Time frame
Metabolites. Timepoint: 2 weeks after the end of the exposure session. Method of measurement: Using LC-MS/MS.;Metabolite intensity. Timepoint: 2 weeks after the end of the exposure session. Method of measurement: Using LC-MS/MS.;Total number of metabolites in participants. Timepoint: 2 weeks after the end of the exposure session. Method of measurement: Using LC-MS/MS.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Sadegh Hassanvand

Tehran University of Medical Sciences

hassanvand@tums.ac.ir+98 21 8895 4914

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026