Effects of Mesna on Reducing Lipid Peroxidation via Malondialdehyde Measurement in Coronary Artery Bypass Graft Surgery

Evaluation of the Effects of Mesna on Reducing Lipid Peroxidation via Malondialdehyde Measurement in Coronary Artery Bypass Graft Surgery: A Double-Blind, Parallel, Placebo-Controlled Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260110068598N1

Enrollment

Registered

2026-01-13

Start date

2026-01-21

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Graft Surgery.

Interventions

Intervention 1: Intervention group: 1600 mg of Mesna will be infused through central venous catheter after turning on the cardiac pump before aorta clamp in CABG (Coronary artery bypass grafting) proc

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: CABG surgery candidate Written consent Age over 18 years old Patients with ejection fraction lower than 50%

Exclusion criteria

Exclusion criteria: Kidney impairment(ClCr 120kg or Body surface area > 2M^2 (square metre) Use of systemic antioxidants in the 7 days before surgery and up to surgery Use of corticosteroid pulse before surgery (7 days before and until 24 hours after surgery)

Design outcomes

Primary

Measure	Time frame
Lipid Peroxidation. Timepoint: Before CABG surgery and 2, 4 , 6 hours after CABG. Method of measurement: Malondialdehyde.	—

Secondary

Measure	Time frame
Hospitalization time. Timepoint: Hospitalization duration after CABG surgery. Method of measurement: length of hospital stay.;Troponin enzyme. Timepoint: Before surgery and 2, 4 , 6 weeks after surgery. Method of measurement: Blood sample.;Creatine kinase. Timepoint: Before surgery and 2, 4 , 6 weeks after surgery. Method of measurement: Blood sample.;Ejection fraction. Timepoint: Before surgery and discharge. Method of measurement: Echocardiography.;Drug history. Timepoint: Before surgery and medications administration after 48 hours of surgery. Method of measurement: patient of documents.;Bleeding volume. Timepoint: 24 hours after surgery. Method of measurement: Drain output.	—

Measure

Time frame

Hospitalization time. Timepoint: Hospitalization duration after CABG surgery. Method of measurement: length of hospital stay.;Troponin enzyme. Timepoint: Before surgery and 2, 4 , 6 weeks after surgery. Method of measurement: Blood sample.;Creatine kinase. Timepoint: Before surgery and 2, 4 , 6 weeks after surgery. Method of measurement: Blood sample.;Ejection fraction. Timepoint: Before surgery and discharge. Method of measurement: Echocardiography.;Drug history. Timepoint: Before surgery and medications administration after 48 hours of surgery. Method of measurement: patient of documents.;Bleeding volume. Timepoint: 24 hours after surgery. Method of measurement: Drain output.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKehan Mohammadi

Tehran University of Medical Sciences

keyhanmohammadi72@yahoo.com+98 21 6658 1692

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026