Comparison of the effects of chlorhexidine 2% and betadine in disinfecting the insertion site of indwelling venous catheters in neonates admitted to the neonatal intensive care unit during the hospitalization period.

Investigating the effect of using antiseptic solutions containing chlorhexidine 2% compared to povidone-Iodine solution in disinfecting the venous catheter placement site in the incidence of catheter associated infections in admitted infantsin the neonatal intensive care unit (NICU)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260108068588N1

Enrollment

100

Registered

2026-02-10

Start date

2026-02-11

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter-related bloodstream infections. Other and unspecified infectious diseases

Interventions

Intervention 1: Intervention group: Infants who received 2% chlorhexidine solution to disinfect the intravenous catheter insertion site. Intervention 2: Control group: Use of povidone iodine solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Newborns admitted to the neonatal intensive care unit Newborns requiring indwelling intravenous catheters during their stay in the neonatal intensive care unit Preterm newborns

Exclusion criteria

Exclusion criteria: Parents' lack of consent to the infant's inclusion in the study No need for hospitalization for more than 3 days in the neonatal intensive care unit Evidence of sepsis before intravenous catheter placement in the neonate

Design outcomes

Primary

Measure	Time frame
Gestational age. Timepoint: Weeks from fertilization. Method of measurement: Pregnancy Calendar.;Durability of the catheter in the infant's body. Timepoint: Days with a catheter in the body. Method of measurement: Difference between catheter insertion and removal dates.;Peripheral blood culture. Timepoint: 6 days after catheter insertion. Method of measurement: Blood sample.;Catheter culture after removal. Timepoint: After catheter removal. Method of measurement: Peripheral blood culture tests, catheter culture, skin culture.;Skin culture immediately after disinfection. Timepoint: Immediately after disinfection. Method of measurement: A sterile cotton swab is applied to the disinfected skin and sent for culture.	—

Measure

Time frame

Gestational age. Timepoint: Weeks from fertilization. Method of measurement: Pregnancy Calendar.;Durability of the catheter in the infant's body. Timepoint: Days with a catheter in the body. Method of measurement: Difference between catheter insertion and removal dates.;Peripheral blood culture. Timepoint: 6 days after catheter insertion. Method of measurement: Blood sample.;Catheter culture after removal. Timepoint: After catheter removal. Method of measurement: Peripheral blood culture tests, catheter culture, skin culture.;Skin culture immediately after disinfection. Timepoint: Immediately after disinfection. Method of measurement: A sterile cotton swab is applied to the disinfected skin and sent for culture.

—

Secondary

Measure	Time frame
Contact dermatitis. Timepoint: Within 1 to 5 days after disinfection. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolab Bostanchi

Shahid Beheshti University of Medical Sciences

gbos8805@gmail.com+98 21 5506 2628

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026