Comparing the Effects of Adenosine Injection on Heart Status and Clinical Outcomes in Patients Undergoing Bypass Surgery (CABG)

Comparative Study of Vasoactive-Inotropic Score, Clinical, Laboratory, and Myocardial Protective Outcomes in Patients Undergoing Cardiopulmonary Bypass Surgery (CABG) With and Without Adenosine Administration- A clinical trial stuady

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20260104068545N1

Enrollment

Registered

2026-05-22

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laboratory Changes in Coronary Artery Bypass Graft (CABG) Patients. Atherosclerotic heart disease of native coronary artery

Interventions

Intervention 1: Intervention group: Patients received 250 micrograms of adenosine per kilogram (manufactured by Exir Company) in two doses: the first dose was 125 micrograms per kilogram administered

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing cardiopulmonary bypass surgery Patients with Ejection Fraction (EF) > 30%

Exclusion criteria

Exclusion criteria: History of Percutaneous Coronary Intervention (PCI) Use of Intra-aortic Balloon Pump (IABP) Presence of Chronic Kidney Disease. Presence of Acute Kidney Disease.

Design outcomes

Primary

Measure	Time frame
Ventilation duration in the intensive care unit (ICU). Timepoint: After the intervention and within 6 hours post-intervention. Method of measurement: Ventilation Time Registration Checklist.;Duration of ICU Admission. Timepoint: After the intervention and within 72 hours post-intervention. Method of measurement: ICU Length of Stay Registration Checklist.;Ejection fraction percentage in the questionnaire. Timepoint: Pre-intervention and 2 weeks post-intervention. Method of measurement: By echocardiography.;CK-MB level. Timepoint: Pre-intervention and 6 hours post-intervention. Method of measurement: CK-MB test kit.;Urea. Timepoint: Post-intervention and 12 hours post-intervention. Method of measurement: Urea test kit.;Creatinine. Timepoint: Post-intervention and 12 hours post-intervention. Method of measurement: Creatinine test kit.;Vasoactive Inotropic Score. Timepoint: Post-intervention and 24 hours post-intervention. Method of measurement: Using the standard formula for calculating the Vasoactive Inotropic Score (VIS).	—

Measure

Time frame

Ventilation duration in the intensive care unit (ICU). Timepoint: After the intervention and within 6 hours post-intervention. Method of measurement: Ventilation Time Registration Checklist.;Duration of ICU Admission. Timepoint: After the intervention and within 72 hours post-intervention. Method of measurement: ICU Length of Stay Registration Checklist.;Ejection fraction percentage in the questionnaire. Timepoint: Pre-intervention and 2 weeks post-intervention. Method of measurement: By echocardiography.;CK-MB level. Timepoint: Pre-intervention and 6 hours post-intervention. Method of measurement: CK-MB test kit.;Urea. Timepoint: Post-intervention and 12 hours post-intervention. Method of measurement: Urea test kit.;Creatinine. Timepoint: Post-intervention and 12 hours post-intervention. Method of measurement: Creatinine test kit.;Vasoactive Inotropic Score. Timepoint: Post-intervention and 24 hours post-intervention. Method of measurement: Using the standard formula for calculating the Vasoactive Inotropic Score (VIS).

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Secondary

Measure	Time frame
Cross clamp Time. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Measured in minutes (by timer).;Duration of pumping time. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Measured in minutes (by timer).;Duration of Cardiac Arrest. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Measured in minutes (by timer).;Number of Grafts at End of Surgery. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Graft Count Registration Checklist.	—

Measure

Time frame

Cross clamp Time. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Measured in minutes (by timer).;Duration of pumping time. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Measured in minutes (by timer).;Duration of Cardiac Arrest. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Measured in minutes (by timer).;Number of Grafts at End of Surgery. Timepoint: During Cardiopulmonary Bypass (CPB). Method of measurement: Graft Count Registration Checklist.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAziz naderzadeh

Birjand University of Medical Sciences

naderzade.aziz81@gmail.com+98 51 3603 4562

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026