Kidney transplant. Kidney transplant failure
Conditions
Interventions
Intervention 1: Intervention group: the intervention group will receive a 20% Mannitol (D-Mannitol) solution intravenously during surgery. The drug dosage is calculated based on body weight (0.5 mL/kg
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: First-time kidney transplant recipient Age 18–70 years Surgery within the study period Multidisciplinary team approval (Psychiatry, Nephrology, Surgery) Transplant benefits outweigh risks Tolerates surgery and immunosuppression
Exclusion criteria
Exclusion criteria: Underwent renal autotransplantation Known hypersensitivity to mannitol Any adverse reaction that cannot be controlled during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delayed Graft Function. Timepoint: 10 days post-transplant. Method of measurement: Clinical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine level. Timepoint: Up to 10 days after transplantation. Method of measurement: Test.;24-hour urine volume. Timepoint: 24 hours after receiving the transplant. Method of measurement: Test.;Deaths. Timepoint: Up to 3 months after transplantation. Method of measurement: Follow-up.;Cold ischemic time. Timepoint: During the transplant operation. Method of measurement: observation.;Warm Ischemic Time. Timepoint: During the transplant operation. Method of measurement: observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaber Khoramabadi
Iran University of Medical Sciences
Outcome results
None listed