Recurrent laryngeal papillomatosis (juvenile-onset recurrent respiratory papillomatosis), a benign HPV-related disease of the larynx characterized by recurrent papillomatous lesions requiring repeated surgical interventions.. Benign neoplasm of larynx
Conditions
Interventions
Intervention group: Intervention group: Intralesional bevacizumab injection as an adjuvant to standard surgical debulking for recurrent laryngeal papillomatosis in children.
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: Children aged =18 years Confirmed diagnosis of recurrent laryngeal papillomatosis based on clinical and/or histopathological findings History of recurrent disease requiring repeated surgical intervention Candidate for surgical debulking with intralesional bevacizumab injection Written informed consent obtained from parents or legal guardians
Exclusion criteria
Exclusion criteria: Known hypersensitivity or contraindication to bevacizumab Presence of uncontrolled bleeding disorders Severe concomitant systemic disease precluding surgery or anesthesia Incomplete medical records or inability to complete follow-up Concomitant use of other adjuvant therapies affecting recurrence rate (if applicable)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first recurrence of laryngeal papillomatosis after intralesional bevacizumab (adjuvant to surgical debulking). Timepoint: From the date of intervention to the date of first documented recurrence, assessed during follow-up (up to 12 months). Method of measurement: Recurrence will be determined by clinical assessment and endoscopic laryngeal examination (and operative findings if re-intervention is required). Dates of intervention and first confirmed recurrence/need for repeat surgery will be recorded to calculate the interval. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactArya jafari
Iran University of Medical Sciences
Outcome results
None listed