Kidney failure. ST elevation (STEMI) myocardial infarction involving left main coronary artery
Conditions
Interventions
Intervention 1: Intervention group (SGLT2 inhibitor): In addition to standard care, patients receive empagliflozin 10 mg orally once daily, starting 24 hours before angiography and continuing for 72 h
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age 18 years or older .Scheduled for coronary angiography (elective or emergency) using iodinated contrast. Have normal renal parameters (eGFR = 60 mL/min/1.73m²) or history of chronic kidney disease with eGFR = 30 mL/min/1.73m².
Exclusion criteria
Exclusion criteria: Patients with known chronic kidney disease Baseline creatinine greater than 1.5 mg/dL Significant hypotension Anemia Patients with acute myocardial infarction undergoing emergency PCI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of contrast-induced acute kidney injury (CI-AKI), defined as an increase in serum creatinine =0.3 mg/dL or =50% from baseline within 48–72 hours after angiography. Timepoint: Patients in both groups will be hospitalized for at least 72 hours after angiography to perform clinical and laboratory assessments (creatinine, eGFR, and metabolic parameters). Method of measurement: Serum Creatinine: Within the normal range of the reference laboratoryeGFR (Estimated Glomerular Filtration Rate): = 60 mL/min/1.73m²BUN (Blood Urea Nitrogen): Within the normal rangeOther parameters related to kidney function (Na, K, etc.) are also recorded and examined quantitatively. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactPeyman Izadpanah
Shiraz University of Medical Sciences
Outcome results
None listed