Coronary artery disease in patients undergoing coronary artery bypass grafting, with risk of postoperative atrial fibrillation.. Presence of aortocoronary bypass graft
Conditions
Interventions
Intervention 1: Intervention group: Patients receive preventive oral amiodarone at a dose of 5 milligrams per kilogram per day, divided into two daily doses, starting 5 days before coronary artery byp
Sponsors
Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria included patients aged =18 years who were admitted to Dr. Heshmat Hospital, Rasht, with non–ST-segment elevation acute coronary syndrome (NSTE-ACS), underwent coronary angiography, were subsequently considered candidates for coronary artery bypass grafting (CABG), remained hospitalized for at least 5 days prior to surgery, and provided written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria included patients undergoing emergency CABG, CABG combined with valvular surgery, redo CABG, a history of hypersensitivity or toxicity to amiodarone, a prior history of atrial fibrillation, chronic amiodarone therapy, diabetes mellitus, hypothyroidism or hyperthyroidism, hepatic failure, abnormal laboratory findings such as serum creatinine >2 mg/dL or elevations of SGOT or SGPT greater than twice the upper limit of normal, chronic obstructive pulmonary disease, preoperative atrial fibrillation, pregnancy, moderate or greater left atrial enlargement on echocardiography, bradycardia with a heart rate <50 beats per minute, left ventricular ejection fraction <40%, or refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of atrial fibrillation after coronary artery bypass grafting surgery. Timepoint: Continuous monitoring during the first six days after surgery, including intensive care unit and hospital ward stay. Method of measurement: Electrocardiogram monitoring using hospital standard electrocardiogram devices. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNiloufar Akbari Parsa
Guilan University of Medical Sciences
Outcome results
None listed