Comparison of two different doses of remifentanil combined with propofol for maintenance of anesthesia on the severity of cough and laryngospasm in elective upper limb orthopedic surgeries

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251228068470N1

Enrollment

Registered

2026-04-04

Start date

2026-03-21

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparison of Two Different Doses of Remifentanil Combined with Propofol for Anesthesia Maintenance on the Severity of Coughing and Laryngospasm in Elective Upper Limb Orthopedic Surgeries. Symptoms, sign and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention 1: Intervention group: 0.01 Microgram/kg/min Remifentanil with 100 macrogram/kg/min Propofol infusion. Intervention 2: Intervention group: 0.04 Microgram/kg/min Remifentanil with 100 macr

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 75 years Physical status of patients classified as ASA I–II Referred to the Orthopedic Surgery Department of Shahid Mohammadi Hospital, Payambar Azam Complex Candidate for upper limb surgery

Exclusion criteria

Exclusion criteria: Failure to complete the informed consent form to participate in the study Lack of necessary conditions to receive anesthesia Underlying heart diseases Patients without hemodynamic stability Allergy to propofol Emergency surgery Patients with long surgeries Immunocompromised patients Recent cold Patients with chronic and acute lung diseases Patients who use drugs

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring.;Diastolic blood pressure. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring.;Mean Arterial blood Pressure. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring.;Heart rate. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring and pulse Oximetry.;Blood O2 Saturation. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Pulse Oximetry.;Cough. Timepoint: After the endotracheal tube is removed and in recovery. Method of measurement: Count the number of coughs, measure the duration of cough with a timer. The number of coughs is divided into no cough (0), mild (1-2), moderate (3-4) and severe (>5). The severity of coughs is divided into grade zero (no cough), grade one (cough lasts less than 3 seconds) and grade two (cough lasts more	—

Measure

Time frame

Systolic blood pressure. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring.;Diastolic blood pressure. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring.;Mean Arterial blood Pressure. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring.;Heart rate. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Heart monitoring and pulse Oximetry.;Blood O2 Saturation. Timepoint: Before intubation, immediately after intubation, during the injection of propofol and remifentanil, and every 15 minutes until the end of the procedure, before extubation and immediately after extubation, when entering and leaving recovery. Method of measurement: Pulse Oximetry.;Cough. Timepoint: After the endotracheal tube is removed and in recovery. Method of measurement: Count the number of coughs, measure the duration of cough with a timer. The number of coughs is divided into no cough (0), mild (1-2), moderate (3-4) and severe (>5). The severity of coughs is divided into grade zero (no cough), grade one (cough lasts less than 3 seconds) and grade two (cough lasts more

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMajid Vatan Khah

Bandare-abbas University of Medical Sciences

alifirouzpour79@hums.ac.ir+98 76 3138 5000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026