Comparison of two ventilation modes, ACV and SIMV on hemodynamic parameters and arterial blood gases in multiple trauma patients under mechanical ventilation

Comparison of two ventilation modes: assist control ventilation (ACV) and synchronized intermittent mandatory ventilation (SIMV) on hemodynamic parameters and arterial blood gases in multiple trauma patients undergoing mechanical ventilation admitted to the intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251228068469N1

Enrollment

136

Registered

2026-03-09

Start date

2025-12-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Comparison of two ventilation modes ACV and SIMV of mechanical ventilation. Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention 1: Intervention group: Assist Control Ventilation: A mode of mechanical ventilation in which the ventilator delivers a specified volume or pressure of air for each breath. Intervention 2:

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients who have suffered head and abdominal trauma and require respiratory support with mechanical ventilation are admitted to the intensive care unit

Exclusion criteria

Exclusion criteria: Smoker and opium user patients Patients with a history of abdominal surgery Unstable patients Death of patients 24 hours after admission to the intensive care unit History of chronic lung diseases Severe heart failure Trauma to the chest Acute respiratory distress syndrome

Design outcomes

Primary

Measure	Time frame
Potential of Hydrogen Ion (PH). Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Arterial blood carbon dioxide pressure. Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Arterial blood oxygen pressure. Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Arterial blood bicarbonate. Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Blood oxygen saturation. Timepoint: Every 8 hours during the first 24 hours of intensive care unit admission while connected to a mechanical ventilator. Method of measurement: Pulse oximeter device.;Blood pressure. Timepoint: Every 8 hours during the first 24 hours of intensive care unit admission while connected to a mechanical ventilator. Method of measurement: Cardiac monitoring device.;Heart rate. Timepoint: Every 8 hours during the first 24 hours of intensive care unit admission while connected to a mechanical ventilator. Method of measurement: Pulse oximeter device.;Age. Timepoint: The beginning of the study. Method of measurement: Identity document.;Gender. Timepoint: The beginning of the study. Method of measurement: Identity document.;Pneumothorax. Timepoint: During the first 24 hours of hospitalization in the intensive care unit while connected to a mechanical ventilator. Method of measurement: Clinical examination and chest x-ray.;Pneumomediastinum. Timepoint: During the first 24 hours of hospitalization in the intensive care unit while connected to a mechanical ventilator. Method of measurement: Clinica	—

Measure

Time frame

Potential of Hydrogen Ion (PH). Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Arterial blood carbon dioxide pressure. Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Arterial blood oxygen pressure. Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Arterial blood bicarbonate. Timepoint: Every 12 hours during the first 24 hours of admission to the intensive care unit while connected to a mechanical ventilator. Method of measurement: Arterial blood gas test.;Blood oxygen saturation. Timepoint: Every 8 hours during the first 24 hours of intensive care unit admission while connected to a mechanical ventilator. Method of measurement: Pulse oximeter device.;Blood pressure. Timepoint: Every 8 hours during the first 24 hours of intensive care unit admission while connected to a mechanical ventilator. Method of measurement: Cardiac monitoring device.;Heart rate. Timepoint: Every 8 hours during the first 24 hours of intensive care unit admission while connected to a mechanical ventilator. Method of measurement: Pulse oximeter device.;Age. Timepoint: The beginning of the study. Method of measurement: Identity document.;Gender. Timepoint: The beginning of the study. Method of measurement: Identity document.;Pneumothorax. Timepoint: During the first 24 hours of hospitalization in the intensive care unit while connected to a mechanical ventilator. Method of measurement: Clinical examination and chest x-ray.;Pneumomediastinum. Timepoint: During the first 24 hours of hospitalization in the intensive care unit while connected to a mechanical ventilator. Method of measurement: Clinica

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMajid Vatan Khah

Bandare-abbas University of Medical Sciences

shrmsumi79@hums.ac.ir+98 76 3138 5000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026