Premenstrual Dysphoric Disorder.
Conditions
Interventions
Intervention 1: Intervention group: patient will be treated with 300-600 mg lithium carbonate for 7 days before the menstrual cycle, through the cycle, and for 5 days after. Intervention 2: Control gr
Sponsors
University of social welfare and rehabilitation sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women of reproductive age (18–45 years) with a diagnosis of Premenstrual Dysphoric Disorder (PMDD) according to DSM-5-TR criteria. Willingness to avoid pregnancy during the duration of the research No use of psychotropic medications within the past three months, unless in accordance with the study protocol No use of medications with known Lithium interactions within the past four weeks, unless discontinued under medical supervision
Exclusion criteria
Exclusion criteria: Women aged younger than 18 or older than 45 years Pregnancy or intention to conceive. Severe psychiatric condition or emergency requiring immediate intervention that precludes adherence to the study protocol. Known significant cardiac disease (e.g., arrhythmia, heart failure, or known Brugada syndrome). Known neurological disease or significant intellectual disability. Untreated hypothyroidism. Severe symptomatic anemia Known hepatic disease. Known renal disease. History of psychiatric hospitalization within the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in symptom severity of Premenstrual Dysphoric Disorder. Timepoint: Daily. Method of measurement: Record of Severity of Problems with DRSP questionure. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactsetareh zargar
University of social welfare and rehabilitation sciences
Outcome results
None listed