Alzheimer. Alzheimers disease with late onset
Conditions
Interventions
Intervention 1: Control group: This group will not participate in functional physical exercises-cognitive or in combined functional-cognitive physical exercises with spiritual activities. They will on
Sponsors
Iran Laboratory Network
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of Alzheimer’s disease confirmed by a neurologist. Ability to read and write. Achieving the specified scores on the questionnaires: Khoshavi Religious Identity Questionnaire: scores between 78 and 124 (with emphasis on disagreement with items 22 and 24); Paloutzian and Ellison Spiritual Well-Being Questionnaire: scores between 40 and 80; MoCA Questionnaire: scores below 20. Absence of specific metallic components in the body (as indicated in the informed consent form for fMRI brain mapping). Possessing the minimal physical fitness and readiness to perform functional-cognitive interventions (ability to walk independently or with simple assistive devices such as a cane or walker, a TUG test result of less than 30 seconds, and no advanced cardiopulmonary disease, severe pain, or orthopedic problems that would prevent performing functional exercises).
Exclusion criteria
Exclusion criteria: Strong evidence ruling out other causes of cognitive decline, such as cognitive impairment not resulting from stroke, Parkinson’s disease, vascular dementia, major depression, substance or medication use, or other neurological or psychiatric disorders. History of stroke, traumatic brain injury, or epilepsy within the past six months. Severe sensory-motor impairments that prevent participation in physical exercises (e.g., blindness or severe motor disability). Untreated severe psychotic disorders or major depression that hinder active participation. Use of medications affecting cognitive function (e.g., benzodiazepines) within the past three months. Concurrent participation in other structured cognitive or physical interventions. Participant or family noncompliance in more than 3 consecutive sessions or 20% of the total sessions.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function. Timepoint: At the beginning of the study, prior to the initiation of the intervention, and at the end of the study, following completion of the intervention period (no later than two weeks thereafter). Method of measurement: Montreal Cognitive Assessment + N-Back test + Stroop test + Corsi block tapping test. | — |
Primary
| Measure | Time frame |
|---|---|
| Brain connectivity network. Timepoint: At the beginning of the study, prior to the initiation of the intervention, and at the end of the study, following completion of the intervention period (no later than two weeks thereafter). Method of measurement: functional Magnetic Resonance Imaging. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mohammad Reza Shokrollahi
Shahid Beheshti University
Outcome results
None listed