Coronary artery disease. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: In this group N acetylcysteine at a dose of 1200 milligrams is added to the cardiopulmonary bypass prime solution. The drug is added to the reservoir during prime preparation before in
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Adult patients aged 40 to 80 years Elective candidates for on-pump coronary artery bypass graft surgery Number of grafts two or more Body mass index between 19 and 25 kg/m² Written informed consent for participation in the study
Exclusion criteria
Exclusion criteria: History of asthma or allergy Redo cardiac surgery Left ventricular ejection fraction less than 35 percent Pre-existing liver dysfunction with SGOT or SGPT more than 1.5 times the normal level Preoperative coagulation disorders Pre-existing renal disease with glomerular filtration rate less than 50 ml/min/1.73 m² Emergency surgery Preoperative hemoglobin level less than 10 g/dL Chronic inflammatory diseases such as rheumatoid arthritis, malignancy, or psoriasis Autoimmune diseases or use of immunosuppressive drugs Use of vitamins or nutritional supplements in the preoperative period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum oxidant antioxidant balance. Timepoint: Immediately before initiation of cardiopulmonary bypass and immediately after completion of cardiopulmonary bypass. Method of measurement: Measurement of pro oxidant antioxidant balance using the simultaneous PAB assay by enzyme linked immunosorbent assay method, reported as numerical values in Hamidi Koliakos units.;Blood urea nitrogen. Timepoint: Before entry to the operating room; upon admission to the intensive care unit; 24 hours after admission to the intensive care unit; 48 hours after admission to the intensive care unit. Method of measurement: Measurement of serum blood urea nitrogen using standard laboratory biochemical assays, reported in milligrams per deciliter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate. Timepoint: Before entry to the operating room; upon admission to the intensive care unit; 24 hours after admission; 48 hours after admission. Method of measurement: Calculation of glomerular filtration rate based on serum creatinine using a standard formula, reported as milliliters per minute per 1.73 square meters.;C reactive protein. Timepoint: Before surgery; 72 hours after admission to the intensive care unit. Method of measurement: Measurement of serum C reactive protein using standard quantitative laboratory methods.;Erythrocyte sedimentation rate. Timepoint: Before surgery; 72 hours after admission to the intensive care unit. Method of measurement: Measurement of erythrocyte sedimentation rate using standard laboratory methods.;Length of intensive care unit stay. Timepoint: From admission to the intensive care unit until discharge from the unit. Method of measurement: Recording duration of intensive care unit stay in hours based on medical records.;Duration of mechanical ventilation. Timepoint: From admission to the intensive care unit until extubation. Method of measurement: Recording duration of mechanical ventilation in hours based on medical records.;Vasopressor inotropic score. Timepoint: At admission to the intensive care unit; 6 hours after admission; 24 hours after admission; 48 hours after admission. Method of measurement: Calculation of the vasopressor inotropic score based on the administered doses of vasopressor and inotropic agents using the following formula:Vasopressor inotropic score = ([Dopamine + Dobutamine] × 1) + (Milrinone × 15) + ([Epinephrine + Norepinephrine + Isoproterenol] × 100).;Serum creatinine. Timepoint: Before entry to the operating room; upon admission to the intensive care unit; 24 hours after admission; 48 hours after admission. Method of measurement: Measurement of serum creatinine using standard laboratory biochemical assays, reported in milligrams per deciliter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contacthamidreza hoseinikhah
Mashhad University of Medical Sciences
Outcome results
None listed