Evaluation of the effect of platelet-rich plasma (PRP) injection on the union rate

Evaluation of the effect of platelet-rich plasma (PRP) injection on the union rate of diaphyseal tibial fractures in patients treated with intramedullary nailing

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251213068298N1

Enrollment

Registered

2026-04-25

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Union of tibial shaft fracture. Fracture of shaft of tibia

Interventions

Intervention 1: Intervention group: Injection of platelet-rich plasma (PRP) at the fracture site immediately after standard surgery. Intervention 2: Control group: Standard fracture surgery.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diaphyseal tibial fractures that are candidates for closed intramedullary nailing (IMN). Age over 18 years

Exclusion criteria

Exclusion criteria: Refusal to continue participation in the study Open fractures Patients who cannot undergo surgery within 72 hours after injury due to clinical conditions Pathologic fractures and low-energy fractures. Use of chemotherapeutic drugs within one month prior to the study. Patients with hematologic disorders, such as cytopenia Failure of previous surgical treatment (device failure).

Design outcomes

Primary

Measure	Time frame
Tibial fracture union rate. Timepoint: Three and six month. Method of measurement: Radiographic union score for tibial fractures(RUST).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Abdolalian

Iran University of Medical Sciences

AbdulAliyan.m@iums.ac.ir+98 21 8214 1205

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026