Investigation the effect of silymarin on liver function

Investigation the effect of silymarin consumption on liver enzyme levels in patients with acne vulgaris eligible for isotretinoin.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251211068289N1

Enrollment

200

Registered

2025-12-25

Start date

2025-12-22

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: The group treated with oral silymarin, who consumed one 140 mg silymarin capsule daily, which is milk thistle extract, for one month. Intervention 2: Control group:

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: suffering from acne vulgaris candidate for oral isotretinoin

Exclusion criteria

Exclusion criteria: liver failure

Design outcomes

Primary

Measure	Time frame
Serum level of AST. Timepoint: At the beginning and 1 month after start of study. Method of measurement: Serum level check.;Serum level of ALT. Timepoint: At the beginning and 1 month after start of study. Method of measurement: Serum level check.;??? ???? ALP. Timepoint: At the beginning and 1 month after start of study. Method of measurement: Serum level check.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Shoushtarizadeh

Esfahan University of Medical Sciences

shoushtarizadeh@resident.mui.ac.ir+98 939 449 3680

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026