The effect of high-intensity interval training on the gut-heart axis in cardiac patients

The effect of a period of high-intensity interval training on short-chain fatty acids (SCFAs) and trimethylamine N-oxide (TMAO) in patients with heart failure with preserved ejection fraction (HFpEF)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251211068287N6

Enrollment

Registered

2026-05-23

Start date

2026-05-31

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure. Body mass index (BMI) pediatric, greater than or equal to 95th percentile for age

Interventions

Intervention 1: Intervention group: High intensity interval training:: This group will perform an interval training program on a treadmill or stationary cycle for 12 weeks, with 3 sessions per week (o

Eligibility

Sex/Gender

All

Age

50 Years to 65 Years

Inclusion criteria

Inclusion criteria: En Symptomatic stable heart failure with preserved ejection fraction (HFpEF) (diagnosed based on the European Society of Cardiology criteria: Paulus et al., 2007). LVEF =50% Being aged between 50 and 65 years Diastolic dysfunction ((E/e‘ >15 or E/e‘ 8-15 + NT-proBNP > 220 pg/ml resp. BNP > 80ng/l)

Exclusion criteria

Exclusion criteria: Unwillingness to sign a written commitment to regular session attendance Presence of acute inflammatory joint diseases that contraindicate physical exercise. A history of major surgery or acute myocardial infarction within the preceding 6 months . Lack of physical or neuromuscular ability to perform the exercise protocol.

Design outcomes

Primary

Measure	Time frame
Serum short-chain fatty acids (SCFAs) levels. Timepoint: Measurements will be conducted at two time points: before the intervention begins and 48 hours after completion of the 12-week exercise period. Method of measurement: Measured using the ELISA method.;Serum trimethylamine N-oxide (TMAO) level. Timepoint: Measurements will be conducted at two time points: before the intervention begins and 48 hours after completion of the 12-week exercise period. Method of measurement: Measured using the ELISA method.	—

Measure

Time frame

Serum short-chain fatty acids (SCFAs) levels. Timepoint: Measurements will be conducted at two time points: before the intervention begins and 48 hours after completion of the 12-week exercise period. Method of measurement: Measured using the ELISA method.;Serum trimethylamine N-oxide (TMAO) level. Timepoint: Measurements will be conducted at two time points: before the intervention begins and 48 hours after completion of the 12-week exercise period. Method of measurement: Measured using the ELISA method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNajmeh Rezaeinezhad

University of Tehran

n.rezaeinezhad@ut.ac.ir+98 912 725 8637

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026