Cardiac Patients. Heart failure, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Moderate-Intensity Continuous Training (MICT) Group: This group will perform a continuous exercise program on a treadmill or stationary cycle for 12 weeks, with 3 s
Sponsors
University of Tehran
Eligibility
Sex/Gender
Male
Age
50 Years to 65 Years
Inclusion criteria
Inclusion criteria: Symptomatic stable heart failure with preserved ejection fraction (HFpEF) (diagnosed based on the European Society of Cardiology criteria: Paulus et al., 2007). LVEF = 50% Diastolic dysfunction ((E/e‘ >15 or E/e‘ 8-15 + NT-proBNP > 220 pg/ml resp. BNP > 80ng/l) Being aged between 50 and 65 years.
Exclusion criteria
Exclusion criteria: Unwillingness to sign a written commitment to regular session attendance. Presence of acute inflammatory joint diseases that contraindicate physical exercise. A history of major surgery or acute myocardial infarction within the preceding 6 months. Lack of physical or neuromuscular ability to perform the exercise protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuregulin. Timepoint: Measurements will be conducted at two time points: before the intervention begins and 48 hours after completion of the 12-week exercise period. Method of measurement: Measured using the ELISA method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation marker. Timepoint: Measurements will be conducted at two time points: before the intervention begins and 48 hours after completion of the 12-week exercise period. Method of measurement: Using the ELISA method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNajmeh Rezaeinezhad
University of Tehran
Outcome results
None listed