The effect of specific exercise training combined with turmeric extract consumption on disease factors in improving multiple sclerosis.

The Effect of Concurrent Exercise Training with Curcumin Supplementation on the Expression of miRNA-146a, miRNA-155, and miRNA-135-5p Involved in the NF-?B Signaling Pathway in Women Diagnosed with Multiple Sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251209068269N1

Enrollment

Registered

2026-02-17

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group1: Participants in this group will participate in a combined resistance and aerobic exercise program based on existing guidelines and will take 500 mg of oral curcumi

Eligibility

Sex/Gender

Female

Age

25 Years to 40 Years

Inclusion criteria

Inclusion criteria: Gender: Female Relapsing-Remitting Multiple Sclerosis EDSS less than 5 No Exercise Training at least 5 month No History of Other Diseases No use of steroid medications within the three months preceding study initiation

Exclusion criteria

Exclusion criteria: Other Types of Multiple Sclerosis Reduced ability to move independently

Design outcomes

Primary

Measure	Time frame
MiRNA-146a. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: It is measured using special kits and a real-time PCR device.;MiRNA-155. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: It is measured using special kits and a real-time PCR device.;Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: It is measured using special kits and a real-time PCR device.;Cholesterol. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;Triglyceride. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;Low-density lipoprotein cholesterol. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;High-density lipoprotein cholesterol. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;Muscle Strength. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Participants' wrist muscle strength is measured using a hand-held dynamometer.	—

Measure

Time frame

MiRNA-146a. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: It is measured using special kits and a real-time PCR device.;MiRNA-155. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: It is measured using special kits and a real-time PCR device.;Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: It is measured using special kits and a real-time PCR device.;Cholesterol. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;Triglyceride. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;Low-density lipoprotein cholesterol. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;High-density lipoprotein cholesterol. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Measurements are performed using special ELISA kits.;Muscle Strength. Timepoint: Before the start of the interventions and after 12 weeks of implementing the exercise interventions. Method of measurement: Participants' wrist muscle strength is measured using a hand-held dynamometer.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVazgen Minasian

The University of Isfahan

v.minasian@spr.ui.ac.ir+98 31 3627 8066

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026