High Blood Pressure. Essential (primary) hypertension
Conditions
Interventions
Intervention 1: Standardized extract of the plant Ajwain (Trachyspermum ammi).Form and Dosage: This group will receive 250 mg oral capsules containing the Ajwain extract.Standardization and Compositio
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Diagnosis of Hypertension Antihypertensive Medication Use Informed Consent and Protocol Adherence People between the ages of 20 and 60
Exclusion criteria
Exclusion criteria: Pregnant or lactating women Patients with severe hepatic or renal impairment Individuals with specific cardiovascular diseases, such as severe aortic stenosis, acute heart failure, or unstable cardiovascular diseases (e.g., unstable angina), where the condition may be exacerbated by changes in blood pressure. The presence of acute infectious or inflammatory diseases at the time of study initiation History of any allergic reaction to Ajwain or other plants of the Apiaceae family (such as celery, parsley) History of any intolerable and severe side effects, such as severe drop in blood pressure (hypotension) or allergic reaction to antihypertensive drugs Consumption of alcohol or other drugs that may affect drug metabolism and general health status. A person taking calcium channel blockers (such as Amlodipine, Nifedipine, and Diltiazem) will not be enrolled in the study because the potential interaction of Ajwain with these drugs may cause a synergistic effect and lead to hypotension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: At the start of the study, week four, week eight. Method of measurement: Blood Pressure Monitors.;Diastolic blood pressure. Timepoint: At the start of the study, week four, week eight. Method of measurement: Blood Pressure Monitors. | — |
Secondary
| Measure | Time frame |
|---|---|
| HDL Cholesterol. Timepoint: At the start of the study, week eight. Method of measurement: Measuring the amount of HDL in patients' blood samples.;LDL Cholesterol. Timepoint: At the start of the study, week eight. Method of measurement: Measuring the amount of LDL in patients' blood samples.;Triglycerides. Timepoint: At the start of the study, week eight. Method of measurement: Measuring the amount of triglycerides in patients' blood samples.;ALT enzyme level. Timepoint: At the start of the study, week eight. Method of measurement: Measuring the amount of ALT enzyme measured in patients' blood samples.;AST enzyme level. Timepoint: At the start of the study, week eight. Method of measurement: Measuring the amount of AST enzyme measured in patients' blood samples.;FBS Level. Timepoint: At the start of the study, week eight. Method of measurement: Measuring blood sugar after fasting for at least 8 hours. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadhasan Fakhari Zavareh
Bagheiat-allah University of Medical Sciences
Outcome results
None listed